磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体

磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体

〖别名〗alpha B Crystallin (phospho S59); alpha B Crystallin (phospho Ser59); p-alpha B Crystallin (S59); p-alpha B Crystallin (Ser59); AACRYA; Alpha B crystallin; Alpha crystallin B chain; Alpha crystallin B chain; Alpha(B) crystallin; Alpha(B)-crystallin; Alpha-crystallin B chain; CRYA2; CRYAB; CRYAB_HUMAN; Crystallin alpha B; Crystallin alpha polypeptide 2; CTPP 2; CTPP2; Heat shock 20 kD like protein; Heat shock protein beta 5; Heat shock protein beta-5; HSPB5; NY REN 27 antigen; Renal carcinoma antigen NY REN 27; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component. 

〖浓度〗1mg/1ml 

〖规格〗磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体0.1ml/100μg   

〖抗体来源〗Rabbit  

〖克隆类型〗polyclonal 

〖交叉反应〗Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, Hamster   

〖产品类型〗一抗  磷酸化抗体  

〖研究领域〗肿瘤 细胞生物 信号转导 新陈代谢  

〖蛋白分子量〗predicted molecular weight: 20kDa 

〖性状〗Lyophilized or Liquid 

〖免疫原〗KLH conjugated synthesised phosphopeptide derived from human alpha B Crystallin around the phosphorylation site of Ser59 

〖亚型〗IgG 

〖纯化方法〗affinity purified by Protein A 

〖储存液〗Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

〖产品应用〗WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

〖保存条件〗Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

〖产品介绍〗Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq, Jul 2008].

Function : May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

Subunit : Heteropolymer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Interacts with HSPBAP1 and TTN/titin.

Subcellular Location : Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. 

Tissue Specificity : Lens as well as other tissues.

DISEASE : Defects in CRYAB are the cause of myopathy myofibrillar type 2 (MFM2) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients. 

[DISEASE] Defects in CRYAB are the cause of cataract posterior polar type 2 (CTPP2) [MIM:613763]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity. 

[DISEASE] Defects in CRYAB are the cause of myopathy myofibrillar fatal infantile hypertonic alpha-B crystallin-related (MFMFIH-CRYAB) [MIM:613869]. MFMFIH-CRYAB is a muscular dystrophy with onset in the first weeks of life after a normal neonatal period. Affected infants show rapidly progressive muscular rigidity of the trunk and limbs associated with increasing respiratory difficulty resulting in death before age 3 years.

Similarity : Belongs to the small heat shock protein (HSP20) family. 

Database links : UniProtKB/Swiss-Prot: P02511.2

本公司产品现货供应,货期短，质量可靠。仅用于科研实验不应用于临床。我们用专业的态度，一流的服务，全程实验指导，让你的数据不在成为实验奇谈。选择优质的磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体，你的小伙伴都会惊呆的。本公司专业供应各种进口、国产一抗及二抗。代理品牌有R&D、Santa Cruz、Bipec、Millipore等国际知名品牌，品种多达7000多种。让你的科研之路不再布满荆棘。

我们还可以为客户提供产品说明书。磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体拥有高纯度、高效价、高特异性的特点，可以应用于多种实验。免费送货上门，为您大大节省了时间和金钱。

Ab-(001)-01281 Anti-AFP 甲胎蛋白单克隆抗体(检测) ，英文名： Anti-AFP ，规格： 0.1ml

Ab-(001)-01282 Anti-AGER 晚期糖基化终末产物特异性受体抗体 ，英文名： Anti-AGER ，规格： 0.1ml

Ab-(001)-01283 Anti-AGEs 晚期糖基化终末产物抗体 ，英文名： Anti-AGEs ，规格： 0.1ml

Ab-(001)-01284 Anti-Aggrecan1/ADAMTS-4 软骨蛋白聚糖抗体 ，英文名： Anti-Aggrecan1/ADAMTS-4 ，规格： 0.2ml

Ab-(001)-01285 Anti-Aggrecan2/ADAMTS-5 软骨蛋白聚糖抗体 ，英文名： Anti-Aggrecan2/ADAMTS-5 ，规格： 0.2ml

Ab-(001)-01286 Anti-Agrin 聚集蛋白抗体 ，英文名： Anti-Agrin ，规格： 0.2ml

Ab-(001)-01287 Anti-Angiotensin II type 1A receptor 血管紧张素Ⅱ1A型受体抗体 ，英文名： Anti-Angiotensin ，规格： 0.2ml

Ab-(001)-01288 Anti-Aryl Hydrocarbon Receptor/AHR 芳香烃受体抗体 ，英文名： Anti-Aryl ，规格： 0.2ml

Ab-(001)-01289 Anti-AIF 调亡诱导因子抗体 ，英文名： Anti-AIF ，规格： 0.1ml

Ab-(001)-01290 Anti-AIF 调亡诱导因子抗体 ，英文名： Anti-AIF ，规格： 0.1ml

Ab-(001)-01291 Anti-AIMP2 AIMP2抗体 ，英文名： Anti-AIMP2 ，规格： 0.2ml

Ab-(001)-01292 Anti-Adenylate Kinase 1/ AK1 腺苷酸激酶-1抗体 ，英文名： Anti-Adenylate ，规格： 0.2ml

Ab-(001)-01293 Anti-Aldolase A 醛缩酶A抗体 ，英文名： Anti-Aldolase ，规格： 0.2ml

Ab-(001)-01294 Anti-ALK/CD246 间变型淋巴瘤激酶抗体 ，英文名： Anti-ALK/CD246 ，规格： 0.2ml

Ab-(001)-01295 Anti-phospho-ALK/CD246 (Tyr1604) 磷酸化间变型淋巴瘤激酶抗体 ，英文名： Anti-phospho-ALK/CD246 ，规格： 0.1ml

Ab-(001)-01296 Anti-phospho-ALK/CD246(Tyr1278/1282/1283) 磷酸化间变型淋巴瘤激酶抗体 ，英文名： Anti-phospho-ALK/CD246 ，规格： 0.1ml

Ab-(001)-01297 Anti-phospho-ALK/CD246(Tyr1586) 磷酸化间变型淋巴瘤激酶抗体 ，英文名： Anti-phospho-ALK/CD246 ，规格： 0.1ml

Ab-(001)-01298 Anti-ALR 肝再生增强因子抗体 ，英文名： Anti-ALR ，规格： 0.2ml

Ab-(001)-01299 Anti-Alkaline phosphatase/PLAP 碱性磷酸酶抗体 ，英文名： Anti-Alkaline ，规格： 0.1ml

Ab-(001)-01300 Anti-APS APS抗体 ，英文名： Anti-APS ，规格： 0.2ml

Ab-(001)-01301 Anti-phospho-APS(Ser598) 磷酸化APS抗体 ，英文名： Anti-phospho-APS ，规格： 0.1ml

Ab-(001)-01302 Anti-AP2 alpha 转录激活蛋白2α ，英文名： Anti-AP2 ，规格： 0.2ml

Ab-(001)-01303 Anti-ALT1 谷丙氨酸氨基转移酶1抗体 ，英文名： Anti-ALT1 ，规格： 0.2ml

Ab-(001)-01304 Anti-AMACR α-甲基酰基辅酶A消旋酶抗体 ，英文名： Anti-AMACR ，规格： 0.2ml

Ab-(001)-01305 Anti-Amphiphysin 神经元突触前膜蛋白抗体 ，英文名： Anti-Amphiphysin ，规格： 0.2ml

Ab-(001)-01306 Anti-AMPK alpha 1 腺苷单磷酸活化蛋白激酶α1抗体 ，英文名： Anti-AMPK ，规格： 0.1ml

Ab-(001)-01307 Anti-phospho-AMPK alpha-1(Ser485+Ser491) 磷酸化腺苷单磷酸活化蛋白激酶α1抗体 ，英文名： Anti-phospho-AMPK ，规格： 0.1ml

Ab-(001)-01308 Anti-AMPK alpha 2 腺苷单磷酸活化蛋白激酶α2抗体 ，英文名： Anti-AMPK ，规格： 0.2ml

Ab-(001)-01309 Anti-AMPK beta 1 腺苷单磷酸活化蛋白激酶β1抗体 ，英文名： Anti-AMPK ，规格： 0.1ml

Ab-(001)-01310 Anti-phospho-AMPK beta 1(Ser108) 磷酸化腺苷单磷酸活化蛋白激酶β1抗体 ，英文名： Anti-phospho-AMPK ，规格： 0.1ml

Ab-(001)-01311 Anti-phospho-AMPK beta 1(Ser182) 磷酸化腺苷单磷酸活化蛋白激酶β1抗体 ，英文名： Anti-phospho-AMPK ，规格： 0.1ml

Ab-(001)-01312 Anti-Amylin 糖尿病相关肽/胰岛淀粉样肽抗体 ，英文名： Anti-Amylin ，规格： 0.1ml

Ab-(001)-01313 Anti-beta-Amyloid 1-42(CT) β淀粉样肽1-42 (C端)抗体 ，英文名： Anti-beta-Amyloid ，规格： 0.1ml

Ab-(001)-01314 Anti-beta-Amyloid(1-16) (human) β淀粉样肽（1-16）抗体（人） ，英文名： Anti-beta-Amyloid ，规格： 0.1ml

Ab-(001)-01315 Anti-beta-Amyloid(1-16) β淀粉样肽（1-16）抗体（小鼠、大鼠） ，英文名： Anti-beta-Amyloid ，规格： 0.1ml

Ab-(001)-01316 Anti-beta-Amyloid(31-35) β淀粉样肽（31-35）抗体 ，英文名： Anti-beta-Amyloid ，规格： 0.1ml

Ab-(001)-01317 Anti-beta-Amyloid(1-28) β淀粉样肽（1-28）抗体 ，英文名： Anti-beta-Amyloid ，规格： 0.1ml

Ab-(001)-01318 Anti-beta-Amyloid(1-28) β淀粉样肽（1-28）抗体 ，英文名： Anti-beta-Amyloid ，规格： 0.1ml

Ab-(001)-01319 Anti-beta-Amyloid(25-35) β淀粉样肽（25-35）抗体 ，英文名： Anti-beta-Amyloid ，规格： 0.1ml

Ab-(001)-01320 Anti-beta-Amyloid(1-40) β淀粉样肽（1-40）抗体 ，英文名： Anti-beta-Amyloid ，规格： 0.1ml

Ab-(001)-01321 Anti-beta-Amyloid 1-40(CT) β淀粉样肽1-40(C端)抗体 ，英文名： Anti-beta-Amyloid ，规格： 0.1ml

Ab-(001)-01322 Anti-beta-Amyloid 1-40(CT) β淀粉样肽 1-40 （C端）抗体 ，英文名： Anti-beta-Amyloid ，规格： 0.1ml

Ab-(001)-01323 Anti-beta-Amyloid(1-42) β淀粉样肽（1-42）抗体 ，英文名： Anti-beta-Amyloid ，规格： 0.1ml

Ab-(001)-01324 Anti-Angiopoietin 1 血管生成素-1抗体 ，英文名： Anti-Angiopoietin ，规格： 0.1ml

Ab-(001)-01325 Anti-Angiopoietin 2 血管生成素2抗体 ，磷酸化热休克蛋白β5/αb晶体蛋白质/α-晶体蛋白b链抗体英文名： Anti-Angiopoietin ，规格： 0.1ml

Ab-(001)-01326 Anti-Ankyrin G 锚定蛋白G抗体 ，英文名： Anti-Ankyrin ，规格： 0.2ml

Ab-(001)-01327 Anti-ANP 心钠素抗体 ，英文名： Anti-ANP ，规格： 0.2ml