英文名称 SIGLECL1
中文名称 唾液酸结合性免疫球蛋白样凝集素12抗体
别 名 FLJ38600; S2V; sialic acid binding Ig-like lectin 12 (gene/pseudogene); Sialic acid-binding Ig-like lectin 12; Sialic acid-binding Ig-like lectin-like 1; Sialic acid-binding immunoglobulin-like lectins; SIG12_HUMAN; Siglec-12; Siglec-L1; SIGLEC-like 1; SIGLEC-like gene; SIGLEC-like protein 1; Siglec-XII; Siglec12; SLG.
唾液酸结合性免疫球蛋白样凝集素12抗体
说 明 书 0.2ml
研究领域 细胞生物 细胞膜蛋白
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIGLECL1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
唾液酸结合性免疫球蛋白样凝集素12抗体产品介绍 background:
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Subcellular Location:
Membrane.
Tissue Specificity:
Isoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower expressed in thyroid, placenta, brain, stomach, bone marrow, spinal chord and breast. Isoform Long is highly expressed in spleen, small intestine and bone marrow; it is lower expressed in thyroid, placenta, thymus, trachea, stomach, lung, adrenal gland, fetal brain and testis.
Similarity:
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Database links:
Entrez Gene: 89858 Human
Entrez Gene: 83382 Mouse
Omim: 606094 Human
SwissProt: Q96PQ1 Human
SwissProt: Q91Y57 Mouse
Unigene: 249741 Human
Unigene: 157702 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
唾液酸结合性免疫球蛋白样凝集素12抗体
hz-5083R MTTP 微粒体甘油三酯转运蛋白
hz-5085R MVD 甲羟戊酸脱羧酶抗体
hz-1018R CA15-3/Muc1 粘蛋白-1/上皮膜抗原抗体
hz-1993R Muc2 粘蛋白-2/上皮膜抗原2抗体
hz-1525R mucin3/Muc3 粘蛋白-3抗体
hz-2414R mucin 5B/Muc5B 粘蛋白-5B抗体
hz-1994R Mucin 4/Muc4 粘蛋白-4抗体
hz-5086R MVK 甲羟戊酸激酶抗体
hz-3954R STXBP1/Munc18 神经突触前膜胞内蛋白18抗体
hz-5639R phospho-STXBP1(Ser515) 磷酸化神经突触前膜胞内蛋白抗体
hz-2539R MuRF1/Trim63 肌肉细胞特异性泛素蛋白连接酶1抗体
hz-1047R MyD88 髓样分化蛋白抗体
hz-2380R MYL9 肌球蛋白轻链9抗体
hz-4060R phospho-MYL9(Thr19) 磷酸化肌球蛋白轻链9抗体
hz-3658R NIPP1/ARD1 核抑制蛋白磷酸酶1抗体
hz-0337R Myelin Protein Zero 外周髓磷脂P0蛋白/P0蛋白抗体
hz-2032R PMP2 周围神经髓鞘蛋白2抗体
hz-2166R MYSM1 MYSM1抗体
hz-1267R MYOZ/MYOZ1 MYOZ抗体
hz-2442R MyoD1/Myf3 肌原调节蛋白抗体
hz-5499R phospho-MyoD1(Ser200) 磷酸化肌原调节蛋白抗体
hzt-0509M SM Myosin (Smooth Muscle) 人心肌肌凝蛋白(平滑肌) 小鼠单抗
hz-3805R Myoglobin 肌红蛋白抗体
hz-1038R CHRNA4 烟碱型乙酰胆碱受体α4抗体
hz-1049R CHRNA7 烟碱型乙酰胆碱受体α7抗体
hz-2538R CHRNA2(neuronal) 烟碱型乙酰胆碱受体A2(神经型)抗体
hz-4247R CHRNB2 烟碱型乙酰胆碱受体B2抗体
hz-3682R Nox1/NADPH oxidase 1 有丝分裂氧化酶1抗体
hz-3683R Nox3/NADPH oxidase 3 NADPH oxidase 3抗体
hz-3684R NOX4/NADPH oxidase 4 NADPH氧化酶NOX家族的成员4抗体
hz-0829R Nanog 胚胎干细胞关键蛋白抗体
hz-0452R NAIF1 protein 核凋亡诱导因子蛋白1
hz-0903R Natrexone 纳曲酮抗体IgG
hz-1052R NAP1L1 核小体组装蛋白1抗体
hz-1797R Contactin 6/NB3/CNTN6 神经细胞NB3特定蛋白抗体
hz-2667R Contactin-1 神经细胞表面蛋白F3
hz-1995R P95/NBS1 DNA修复蛋白NBS1抗体
hz-3718R Phospho-p95/NBS1 (Ser343) 磷酸化DNA修复蛋白NBS1抗体
hz-6579R GH/Growth Hormone 生长激素抗体
hz-1172R CDH2/N-cadherin N-钙粘附分子抗体
hz-5263R phospho-CDH2 (Tyr820) 磷酸化N-钙粘附分子抗体
关注
已认证
