英文名称 TOE1
中文名称 早期生长应答蛋白1靶向蛋白1抗体
别 名 Target of EGR1 protein 1; target of EGR1, member 1; Toe1; TOE1_HUMAN.
早期生长应答蛋白1靶向蛋白1抗体
说 明 书 0.2ml
研究领域 细胞生物 免疫学 细胞周期蛋白
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
细胞定位 细胞核
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human TOE1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
早期生长应答蛋白1靶向蛋白1抗体 产品介绍 background:
TOE1 is a 510 amino acid long protein that belongs to the CAF1 family. It is a downstream target of EGR-1 and plays an important role mediating the inhibitory growth effect of EGR-1. EGR-1 directly binds the TOE1 promoter region and activates its expression. TOE1 induces the expression of TGF∫ and p21 and plays a role in cell cycle regulation and the inhibition of cell growth. The activity and nucleolar localization of TOE1 correlates with a G2 cell cycle phase delay which is likely due to an increased expression of p21. In addition, TOE1 may function via an interaction with p53 and possible modification to its activity. TOE1 is expressed at various levels in all adult tissues and specifically localizes to the nuclear speckles.
Function:
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1.
Subcellular Location:
Nucleus > nucleolus. Nucleus speckle. Localizes to nuclear speckles.
Similarity:
Belongs to the CAF1 family.
Contains 1 C3H1-type zinc finger.
Gene ID:
114034
Database links:
Entrez Gene: 114034 Human
Entrez Gene: 68276 Mouse
Entrez Gene: 298443 Rat
Omim: 613931 Human
SwissProt: Q96GM8 Human
SwissProt: Q9D2E2 Mouse
Unigene: 525091 Human
Unigene: 30534 Mouse
Unigene: 105772 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
早期生长应答蛋白1靶向蛋白1抗体
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