IL-1β is a proinflammatory cytokine produced in a variety of cells,
including monocytes, tissue macrophages, keratinocytes, and other
epithelial cells. Both IL-1α and IL-1β bind to the same receptor and
have similar, if not identical, biological properties. These cytokines
have a broad range of activities including the stimulation of thymocyte
proliferation by inducing IL-2 release, B cell maturation and
proliferation, mitogenic FGF-like activity, and the release of
prostaglandin and collagenase from synovial cells. However, whereas
IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated
cytokine. Recombinant Human IL-1β is a 17.3 kDa protein containing 153
amino acid residues.
Manufactured using all Animal-Free reagents.
Source: E.coli
Synonyms: Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP),
Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
AA Sequence: APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL
GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW
YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED50 is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg.
This product has been tested against the WHO standard. International Unit information can be found here.
Calculated Molecular Weight: 17.3 kDa
Accession Number: P01584
Gene ID: 3553
Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)
crossreactivity:
Frog, Human, Monkey, Mouse, Rabbit, Rat, Sheep
Animal-Free Recombinant Human IL-1beta信息由上海远慕生物科技有限公司为您提供,如您想了解更多关于Animal-Free Recombinant Human IL-1beta报价、型号、参数等信息,欢迎来电或留言咨询。除供应Animal-Free Recombinant Human IL-1beta外,上海远慕生物科技有限公司还可为您提供大鼠90kDa热休克蛋白αA1(HSP90αA1)ELISA试剂盒、大鼠14-3-3 蛋白 beta/alpha(YWHAB)ELISA试剂盒、大鼠15-epi-氧脂素 A4(15-epi-LXA4)ELISA试剂盒等产品,公司有专业的客户服务团队,是您值得信赖的合作伙伴。