TGF-β family members are key modulators of cell proliferation,
differentiation, matrix synthesis, and apoptosis. As implied by their
name, BMPs initiate, promote, and regulate the development, growth, and
remodeling of bone and cartilage. In addition to this role, BMPs are
also involved in prenatal development and postnatal growth, remodeling,
and maintenance of a variety of other tissues and organs. BMP-7, also
known as osteogenic protein-1 or OP-1, is a potent bone inducing agent,
which in the presence of an appropriate osteoconductive carrier (e.g.
collagen sponge or synthetic hydroxyapatite) can be used in the
treatment of bone defects. A bone-graft substitute, called OP-1TM
implant, made of recombinant human BMP-7 associated with bovine
bone-derived collagen, has recently been approved by the FDA as a device
for treating critical-size bone fractures. The potential use of BMP-7
in dental reconstructive surgeries is currently under investigation.
Recombinant Human BMP-7 is a homodimeric glycoprotein consisting of two
117 amino acid subunits, which correspond to amino acid residues 315 to
431 of the full-length BMP-7 precursor. Recombinant Human BMP-7 has a
calculated molecular weight of 26.4 kDa; however, due to glycosylation,
the BMP-7 homodimer migrates at an apparent molecular weight of
approximately 25-35 kDa by SDS-PAGE analysis under non-reducing
conditions.
Source: CHO cells
Synonyms: Bone Morphogenetic Protein-7, Osteogenic Protein-1 (OP-1)
AA Sequence (monomer): MANVAENSSS DQRQACKKHE LYVSFRDLGW QDWIIAPEGY AAYYCEGECA FPLNSYMNAT
NHAIVQTLVH FINPETVPKP CCAPTQLNAI SVLYFDDSSN VILKKYRNMV VRACGCH
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.02-0.04 μg/ml.
Calculated Molecular Weight: 26.4 kDa
Accession Number: P18075
Gene ID: 655
Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
Note:
100μg is the largest vial size for this product.
Larger sizes supplied as multiple 100μg vials.
crossreactivity:
Human, Monkey, Mouse, Rat
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