Irisin is a proteolytic hormone released into circulation by skeletal
muscle tissue during acute exercise, and is a derivative of the cleaved
plasma membrane protein Fibronectin type III domain-containing protein 5
(FNDC5). Found in muscle tissue, FNDC5 is synthesized at increased
levels during exercise as a result of the overexpression of the
exercise-responsive transcriptional co-activator PGC-1α (peroxisome
proliferator-activated receptor-γ co-activator-1α). Like its parent
polypeptide, Irisin can induce the browning of subcutaneous adipocytes,
or the conversion of white adipose tissue (WAT or white fat) into brown
(or beige) adipose tissue (BAT or brown fat). Given that brown fat can
undergo thermogenesis, or the physiologic process of heat production,
Irisin contributes to the metabolic process by increasing thermogenic
function and glucose homeostasis. Irisin, thus, represents a link
between exercise and “burning” of fats and/or sugars, and consequently
may have relevance in the development of new treatments for diabetes and
obesity. CHO cell-derived Recombinant Human/Murine/Rat Irisin is a
glycosylated homodimer of 224 amino acid residues, whose monomer
consists of 112 amino acid residues corresponding to the active portion
of the 121-amino-acid length Irisin extracellular domain. Recombinant
Human/Murine/Rat Irisin, appears to form a non-disulfide linked
oligomeric structure in solution, has a calculated theoretical molecular
weight of 25.2 kDa, but migrates at an apparent molecular weight of 28
kDa by SDS-PAGE analysis under reducing conditions due to glycosylation.
Source: CHO cells
Synonyms: Fibronectin type III domain-containing protein 5 (FNDC5), Fibronectin type III repeat-containing protein 2 (FRCP2)
AA Sequence (monomer): DSPSAPVNVT VRHLKANSAV VSWDVLEDEV VIGFAISQQK KDVRMLRFIQ EVNTTTRSCA LWDLEEDTEY IVHVQAISIQ GQSPASEPVL FKTPREAEKM ASKNKDEVTM KE
Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to promote cell survival and growth of rat H9c2 cardio-myoblasts under serum starvation conditions.
Calculated Molecular Weight: 25.2 kDa
Accession Number: Q8NAU1
Gene ID: 252995
Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
Cross Reactivity Cited in References:
Human, Mouse, Rat
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