PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa
polypeptide chains, designated PDGF-A and PDGF-B chains. The three
naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent
mitogens for a variety of cell types, including smooth muscle cells,
connective tissue cells, bone and cartilage cells, and some blood cells.
The PDGFs are stored in platelet α-granules, and are released upon
platelet activation. The PDGFs are involved in a number of biological
processes, including hyperplasia, chemotaxis, embryonic neuron
development, and respiratory tubule epithelial cell development. Two
distinct signaling receptors used by PDGFs have been identified and
named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each
of the three PDGF forms. On the other hand, PDGFR-β interacts with only
PDGF-BB and PDGF-AB. Recombinant Human PDGF-AB is a 26.4 kDa
disulfide-linked dimer, consisting of one α chain and one β chain (234
total amino acids).
Source: E.coli
Synonyms: Platelet-Derived Growth Factor-AB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF), PCGF
AA Sequence: Alpha chain: SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV
KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP
DYREEDTGRP RESGKKRKRK RLKPT
Beta chain: SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: The ED50 as determined by the dose-dependent
stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/ml,
corresponding to a specific activity of ≥ 1 x 106 units/mg.
Calculated Molecular Weight: 26.4 kDa
Accession Number: Alpha: P04085 Beta: P01127
Gene ID: Alpha: 5154 Beta: 5155
Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
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