凋亡诱导受体PLEKHG5抗体

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英文名称  Anti-PLEKHG5

中文名称  凋亡诱导受体PLEKHG5抗体

别    名  Apo 3; APO3; Apoptosis inducing receptor AIR; Apoptosis mediating receptor DR3; Apoptosis mediating receptor TRAMP; DDR3; Death domain receptor 3; DR3; DSMA 4; DSMA4; GEF 720; GEF720; Guanine nucleotide exchange factor 720; KIAA0720; LARD; Lymphocyte associated receptor of death; Novel PH domain containing protein; Pleckstrin homology domain containing family G member 5; Pleckstrin homology domain containing, family G (with RhoGef domain) member 5; PLEKHG 5; Putative NFkB activating protein; RP4 650H14.3; TNFRSF12; Tumor necrosis factor receptor superfamily member 25 precursor; WSL; WSL1.

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human

产品类型  一抗    

研究领域  神经生物学 信号转导 细胞凋亡 转录调节因子 表观遗传学  

蛋白分子量  predicted molecular weight: 43kDa

性    状  Lyophilized or Liquid

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免 疫 原  KLH conjugated synthetic peptide derived from human PLEKHG5 (25-100aa)

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 PLEKHG5 is predominantly expressed in the peripheral nervous system and brain. PLEKHG5 localizes to the cytoplasm, however when cells are stimulated, PLEKHG5 is found near the perinuclear regions. PLEKHG5 contains the highly-conserved DH-PH module which is considered to be the signature motif of the Dbl family of guanine nucleotide exchange factors (GEFs). PLEKHG5 activates the NFkB signaling pathway and may be involved in the control of neuronal cell differentiation. It has been suggested that mutations in the PLEKHG5 gene may lead to autosomal recessive distal spinal muscular atrophy (DSMA). Four isoforms of PLEKHG5 exists due to alternative splicing events.

Function : Receptor for TNFSF12/APO3L/TWEAK. Interacts directlywith the adapter TRADD. Mediates activation of NF-kappa-B andinduces apoptosis. May play a role in regulating lymphocytehomeostasis.

Subunit : Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signalingcascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.

Subcellular Location : Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2:Cell membrane; Single-pass type I membrane protein. Isoform 9: Cell membrane; Single-pass type I membrane protein. Isoform 11: Cell membrane; Single-pass type I membrane protein. Isoform 3:Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Isoform 6: Secreted. Isoform 7: Secreted.Isoform 8: Secreted. Isoform 10: Secreted. Isoform 12: Secreted

Tissue Specificity : Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2:Cell membrane; Single-pass type I membrane protein. Isoform 9: Cell membrane; Single-pass type I membrane protein. Isoform 11: Cell membrane; Single-pass type I membrane protein. Isoform 3:Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Isoform 6: Secreted. Isoform 7: Secreted.Isoform 8: Secreted. Isoform 10: Secreted. Isoform 12: Secreted

Post-translational modifications : Glycosylated (Probable).

Similarity : Contains 1 death domain.

凋亡诱导受体PLEKHG5抗体Contains 4 TNFR-Cys repeats.

Database links : UniProtKB/Swiss-Prot: Q93038.2