多囊肾蛋白1样3抗体

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英文名称  Anti-PKD1L3

中文名称  多囊肾蛋白1样3抗体

别    名  PC1 like 3 protein; Polycystic kidney disease 1 like 3; Polycystic kidney disease protein 1 like 3; Polycystin 1 like 3; Polycystin 1L3;PK1L3_HUMAN.

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human

产品类型  一抗    

研究领域  神经生物学 通道蛋白 细胞膜受体  

蛋白分子量  predicted molecular weight: 193kDa

性    状  Lyophilized or Liquid

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免 疫 原  KLH conjugated synthetic peptide derived from human PKD1L3

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Polycystin-1L3 is a 1,732 amino acid multi-pass membrane protein that contains one PLAT domain, one GPS domain and one C-type lectin domain. Expressed at high levels in placenta and present at lower levels in lung and heart, Polycystin-1L3 is thought to function as an ion-channel regulator that may interact with Polycystin-L and play a role in heteromeric taste channels. The gene encoding Polycystin-1L3 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Function : PKD1L3 belongs to the polycystin family. It may function as an ion-channel regulator and may function with PKD2L1 as heteromeric taste channels.

Subcellular Location : Membrane; Multi-pass membrane protein.

Tissue Specificity : Highly expressed in placenta, weakly in heart and lung.

Similarity : Belongs to the polycystin family.

Contains 1 C-type lectin domain.

多囊肾蛋白1样3抗体Contains 1 GPS domain.

Contains 1 PLAT domain.

Database links : UniProtKB/Swiss-Prot: Q7Z443.1