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当前位置: 上海抚生 > 抗体/抗原 > 丝氨酸/苏氨酸蛋白激酶18

丝氨酸/苏氨酸蛋白激酶18

供货周期: 现货
品牌: GenWay
规格: 0.1ml/100μg和0.2ml/200μg等规格
货号:
CAS号:
报价: ¥1
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产品介绍

我公司是国内最权威的抗体代理商,丝氨酸/苏氨酸蛋白激酶18价格优惠,丝氨酸/苏氨酸蛋白激酶18质量保证,欢迎来电订购或咨询在线客服!

英文名称  Anti-PLK4/STK18

中文名称  丝氨酸/苏氨酸蛋白激酶18

别    名  PLK 4; PLK-4; PLK4; PLK4_HUMAN; Polo like Kinase 4; Polo-like kinase 4; Protein serine/threonine kinase; SAK; Serine/Threonine Kinase 18; Serine/threonine kinase; Serine/threonine protein kinase 18; Serine/threonine protein kinase PLK4; Serine/threonine protein kinase Sak; Serine/threonine-protein kinase 18; Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase SAK; Snk Akin Kinase; STK 18; STK18.

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

产品类型  一抗    

研究领域  细胞生物 免疫学 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学  

蛋白分子量  predicted molecular weight: 108kDa

性    状  Lyophilized or Liquid

丝氨酸/苏氨酸蛋白激酶18着国内抗体行业的崛起,我国自主品牌的抗体,都蛮多了,质量也不错,技术在逐渐成熟,价格也比国外的廉价的多,受到国内顾客的热捧,我们公司为了方便客户,特推出阴离子转运蛋白-1抗体规格15ug、30ug、50ug、100ug,15ug和30ug等,我们全国包邮,大中城市免费快递。抗体分子是生物学和医学领域用途最为广泛的蛋白分子。抗体作为疾病预防、诊断和治疗的制剂已有上百年的发展历史。随着生命科学研究的迅猛发展,抗体工程在生物技术领域越来越占有非常重要的地位。我公司可为您提供快速的、高质量的和经济的多克隆抗体制备服务,并将成为您在科研及生产中的得力助手。

免 疫 原  KLH conjugated synthetic peptide derived from human PLK4/STK18

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500

(石蜡切片需做抗原修复)

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2/CHK2.

Function : Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2.

Subunit : Homodimer (By similarity). Interacts with CEP152 (via N-terminus).

Subcellular Location : Cytoplasm, cytoskeleton, centrosome, centriole. Nucleus, nucleolus (By similarity).

丝氨酸/苏氨酸蛋白激酶18Post-translational modifications : Ubiquitinated; leading to its degradation by the proteasome (By similarity).

Tyrosine-phosphorylated by TEC.

Similarity : Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

Database links : UniProtKB/Swiss-Prot: O00444.3


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企业名称

上海抚生实业有限公司

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信用代码

310112001171431

成立日期

2012-05-02

注册资本

50

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