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英文名称 Anti-PAR3
中文名称 非典型蛋白激酶C特定相互作用蛋白抗体
别 名 par-3; agouti signaling protein; ASIP; Atypical PKC isotype specific interacting protein; CTCL tumor antigen se2-5; PAR3 alpha; par3; par 3; par-3; PARD3; Partitioning-defective 3 homolog.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit
产品类型 一抗
研究领域 肿瘤 免疫学 信号转导 转录调节因子 细胞粘附分子
蛋白分子量 predicted molecular weight: 149kDa
性 状 Lyophilized or Liquid
非典型蛋白激酶C特定相互作用蛋白抗体随着国内抗体行业的崛起,我国自主品牌的抗体,都蛮多了,质量也不错,技术在逐渐成熟,价格也比国外的廉价的多,受到国内顾客的热捧,我们公司为了方便客户,特推出阴离子转运蛋白-1抗体规格15ug、30ug、50ug、100ug,15ug和30ug等,我们全国包邮,大中城市免费快递。抗体分子是生物学和医学领域用途最为广泛的蛋白分子。抗体作为疾病预防、诊断和治疗的制剂已有上百年的发展历史。随着生命科学研究的迅猛发展,抗体工程在生物技术领域越来越占有非常重要的地位。我公司可为您提供快速的、高质量的和经济的多克隆抗体制备服务,并将成为您在科研及生产中的得力助手。
免 疫 原 KLH conjugated synthetic peptide derived from human PAR3.
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 PAR3 is an adapter protein involved in asymmetrical cell division and cell polarization processes. It seems to play a central role in the formation of epithelial tight junctions. Its association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP bound Rho small GTPases to atypical protein kinase C proteins.
Function : Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.
Subunit : Interacts (via PDZ 1 domain) with F11R/JAM1, PARD6A and PARD6B. Isoform 2, but not at least isoform 3 interacts with PRKCZ.Interacts with PRCKI and CDH5. Interacts (via PDZ 3 domain) with PTEN (via C-terminus) (By similarity). Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1,INADL/PATJ and PARD3/PAR3. Interacts with LIMK2, AURKA and AURKB.Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with ECT2 and FBF1.
Subcellular Location : Endomembrane system. Cell junction. Cell junction, tight junction. Cell membrane. Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction.
Tissue Specificity : Widely expressed.
Post-translational modifications : Phosphorylated by PRKCZ. EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2.
非典型蛋白激酶C特定相互作用蛋白抗体Phosphorylation by AURKA at Ser-962 is required for the normal establishment of neuronal polarity.
Similarity : Belongs to the PAR3 family.
Contains 3 PDZ (DHR) domains.