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英文名称 Anti-PDZK3
中文名称 前列腺癌激活蛋白抗体
别 名 Activated in prostate cancer protein; AIPC; KIAA0300; Likely ortholog of rat plakophilin related armadillo repeat protein interacting PDZ protein antibody PAPIN; PDZ domain containing 2; PDZ domain containing 3; PDZ domain containing protein 2; PDZ domain containing protein 3; PDZD2; PDZK 2; PDZK2; PDZK-2; PDZK 3; PDZK3; PDZK-3; PIN1; Plakophilin related armadillo repeat protein interacting PDZ protein like; Rat plakophilin related armadillo repeat protein interacting PDZ protein like; PDZD2_HUMAN.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse
产品类型 一抗
研究领域 肿瘤 细胞生物 免疫学 信号转导
蛋白分子量 predicted molecular weight: 310kDa
性 状 Lyophilized or Liquid
前列腺癌激活蛋白抗体的功能抗体的主要功能是与抗原(包括外来的和自身的)相结合,从而有效地清除侵入机体内的微生物、寄生虫等异物,抗体(antibody)是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活,也可能无效但有时也会对机体造成病理性损害,如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生,对人体可造成危害。
免 疫 原 KLH conjugated synthetic peptide derived from human PDZK3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. PDZK3 contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, the PDZK3 gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.
Subunit : Interacts with SCN10A, CTNND2 and PKP4 (By similarity).
Subcellular Location : Cytoplasmic, Endoplasmic reticulum, Nuclear and Secreted
Tissue Specificity : Isoform 2 is expressed (at protein level) in prostate and many prostate tumors.
Post-translational modifications : A secreted form is produced by caspase-mediated proteolytic cleavage (By similarity).
Similarity : Contains 6 PDZ (DHR) domains.
Database links :
Entrez Gene: 23037 Human
Entrez Gene: 68070 Mouse
前列腺癌激活蛋白抗体Entrez Gene: 65034 Rat
Omim: 610697 Human
SwissProt: O15018 Human
SwissProt: Q9QZR8 Rat