肌萎缩侧索硬化症相关蛋白2（2号染色体）抗体

我公司供应质优价美的科研产品，肌萎缩侧索硬化症相关蛋白2（2号染色体）抗体产品质量保证，提供肌萎缩侧索硬化症相关蛋白2（2号染色体）抗体技术支持，有任何质量问题可免费包退包换，欢迎来电咨询！我们将竭诚为您服务！

英文名称  Anti-PAPK/ALS2CR2

中文名称  肌萎缩侧索硬化症相关蛋白2（2号染色体）抗体

别    名  Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 2; CALS 21; ILP interacting protein ILPIPA; ILPIP; ILPIPA; Likely ortholog of mouse polyploidy associated protein kinase; PAPK; PRO1038.  

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

产品类型  一抗    

研究领域  细胞生物 免疫学 神经生物学 转录调节因子  

蛋白分子量  predicted molecular weight: 34kDa

性    状  Lyophilized or Liquid

肌萎缩侧索硬化症相关蛋白2（2号染色体）抗体的功能抗体的主要功能是与抗原（包括外来的和自身的）相结合，从而有效地清除侵入机体内的微生物、寄生虫等异物，抗体（antibody）是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活，也可能无效但有时也会对机体造成病理性损害，如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生，对人体可造成危害。

免 疫 原  KLH conjugated synthetic peptide derived from human ALS2CR2

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2, is connected to transferase/kinase activity and ATP binding, it has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family. Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1 converting enzyme of Fas-induced apotosis. This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival, suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.

Subunit : Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2

Subcellular Location : Nucleus. Cytoplasm.

肌萎缩侧索硬化症相关蛋白2（2号染色体）抗体Tissue Specificity : Highly expressed in heart, skeletal muscle, testis, liver and colon.

Similarity : Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Contains 1 protein kinase domain.