我公司供应质优价美的科研产品,乳腺癌抑制基因Protor1抗体产品质量保证,提供乳腺癌抑制基因Protor1抗体技术支持,有任何质量问题可免费包退包换,欢迎来电咨询!我们将竭诚为您服务!
英文名称 Anti-Protor-1
中文名称 乳腺癌抑制基因Protor1抗体
别 名 Arhgap8; AU043908; C030017C09Rik; C78947; FLJ20185; FLJ20185k; MGC109513; MGC32512; PP610; Proline rich 5 (renal); Proline-rich protein 5; Protein observed with Rictor-1; Protor-1; PROTOR1; PRR5; PRR5_HUMAN; PTOR1; RP1-181C9.3.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow
产品类型 一抗
研究领域 肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 细胞凋亡 表观遗传学
蛋白分子量 predicted molecular weight: 43kDa
性 状 Lyophilized or Liquid
乳腺癌抑制基因Protor1抗体的功能抗体的主要功能是与抗原(包括外来的和自身的)相结合,从而有效地清除侵入机体内的微生物、寄生虫等异物,抗体(antibody)是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活,也可能无效但有时也会对机体造成病理性损害,如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生,对人体可造成危害。
免 疫 原 KLH conjugated synthetic peptide derived from human Protor-1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Protor-1 plays an important role in regulation of PDGF receptor expression and in modulation of PDGF signaling. It is thought that Protor-1 may act as a tumor suppressor in breast cancer.
Function : Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.
Subunit : Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and RICTOR within the TORC2 complex.
乳腺癌抑制基因Protor1抗体Tissue Specificity : Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors.
Similarity : Belongs to the PROTOR family.
Database links : UniProtKB/Swiss-Prot: P85299.1