蛋白酪氨酸磷酸酶CD148抗体

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英文名称  Anti-PTP/PTPase/CD148

中文名称  蛋白酪氨酸磷酸酶CD148抗体  

别    名  receptor-type tyrosine-protein phosphatase eta isoform 1 precursor; Density enhanced phosphatase 1; Protein tyrosine phosphatase eta; CD148; CD148 antigen; Density enhanced phosphatase 1; DEP 1; DEP1; HPTP eta; Human density enhanced phosphatase 1; Protein tyrosine phosphatase eta;Protein tyrosine phosphatase receptor type J; Protein tyrosine phosphatase receptor type J polypeptide; PTPJ; PTPRJ; R PTP Eta; Receptor type tyrosine protein phosphatase eta; SCC1.

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Rabbit

产品类型  一抗    

研究领域  细胞生物 信号转导 激酶和磷酸酶  

蛋白分子量  predicted molecular weight: 147kDa

性    状  Lyophilized or Liquid

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免 疫 原  KLH conjugated synthetic peptide derived from human PTPRJ C-terminus

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Subcellular Location : Cell membrane.

Tissue Specificity : Expressed in the promyelocytic cell line HL60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the interleukin-3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density.

Similarity : Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

蛋白酪氨酸磷酸酶CD148抗体Contains 9 fibronectin type-III domains.

Contains 1 tyrosine-protein phosphatase domain.