乙型肝炎X相关蛋白2抗体

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英文名称  Anti-XAP2/ARA9

中文名称  乙型肝炎X相关蛋白2抗体

别    名  AH receptor interacting protein; AH receptor-interacting protein; AIP; AIP; AIP_HUMAN; ARA 9; Aryl hydrocarbon receptor interacting protein; Aryl-hydrocarbon receptor-interacting protein; fa03h10; FKBP 16; FKBP 37; FKBP16; FKBP37; HBV X associated protein 2; HBV X associated protein; HBV X-associated protein 2; HBVX associated protein; Immunophilin homolog ARA 9; Immunophilin homolog ARA9; SMTPHN; XAP 2; XAP-2; XAP2.  

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep

产品类型  一抗    

研究领域  细胞生物 神经生物学 通道蛋白 细胞膜受体 细菌及  

蛋白分子量  predicted molecular weight: 38kDa

性    状  Lyophilized or Liquid

乙型肝炎X相关蛋白2抗体的主要功能是与抗原（包括外来的和自身的）相结合，从而有效地清除侵入机体内的微生物、寄生虫等异物，抗体（antibody）是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活，也可能无效但有时也会对机体造成病理性损害，如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生，对人体可造成危害。

免 疫 原  KLH conjugated synthetic peptide derived from human XAP2/ARA9

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 The Aryl hydrocarbon receptor (AhR), also designated dioxin receptor (DR), a ligand-activated transcription factor, becomes activated upon binding of dioxins or structurally related forms of xenobiotics. Upon ligand binding, AhR translocates from the cytoplasm to the nucleus where it complexes with Arnt to form a DNA binding heterodimer. This complex activates transcription of target genes involved in xenobiotic metabolism. Until ligand binding occurs, AhR remains latent in the cytoplasm, which is maintained by its association with the molecular chaperones HSP 90, the hepatitis B virus X-associated protein (XAP2, also designated AIP and ARA9) and the heat shock protein p23. XAP2, a ubiquitously expressed protein, binds to HSP 90 and AhR through a highly conserved carboxy-terminal tetraticopeptide repeat domain. XAP2 participates in stabilizing AhR as well as enhancing the cytoplasmic localization of the receptor. It may also be involved in regulating the degradation of AhR.

Function : signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

Cellular negative regulator of the hepatitis B virus (HBV) X protein.May play a positive role in AHR-mediated (aromatic hydrocarbon receptor)

Subunit : Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.

Subcellular Location : Cytoplasm.

Tissue Specificity : Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.

DISEASE : Defects in AIP are a cause of familial isolated pituitary adenoma (FIPA)

[MIM:102200]. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA) [MIM:102200]; also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma.

Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA) [MIM:219090]; also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.

Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA) [MIM:600634]; also known as prolactinoma. Prolactin-secreting pituitary adenoma is 乙型肝炎X相关蛋白2抗体the most common type of hormonally active pituitary adenoma.

Similarity : Contains 1 PPIase FKBP-type domain.

Contains 2 TPR repeats.

Database links : UniProtKB/Swiss-Prot: O00170.2