磷酸化鸟苷酸转换因子VAV1抗体

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英文名称  Anti-phospho-VAV1(Tyr174)  

中文名称  磷酸化鸟苷酸转换因子VAV1抗体

别    名  VAV1(phospho Y174); Oncogene vav; p95Vav; Protooncogene vav; VAV 1; VAV 1 oncogene; VAV; Vav proto oncogene.

浓    度  1mg/1ml

规 格  0.1ml/100μg

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Dog, Pig, Horse

产品类型  一抗  磷酸化抗体  

研究领域  肿瘤 免疫学 染色质和核信号 信号转导 转录调节因子 激酶和磷酸酶 G蛋白偶联受体 t-淋巴细胞 b-淋巴细胞  

蛋白分子量  predicted molecular weight: 98kDa

性    状  Lyophilized or Liquid

磷酸化鸟苷酸转换因子VAV1抗体的主要功能是与抗原（包括外来的和自身的）相结合，从而有效地清除侵入机体内的微生物、寄生虫等异物，抗体（antibody）是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活，也可能无效但有时也会对机体造成病理性损害，如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生，对人体可造成危害。

免 疫 原  KLH conjugated Synthesised phosphopeptide derived from human VAV1 around the phosphorylation site of Tyr174

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Vav proteins belong to the guanidine nucleotide exchange factor family of proteins that couple receptors to Rho-GTPases. The VAV family has currently three members in mammalian cells (VAV 1, VAV 2, and VAV 3). VAV 1 contains multiple protein binding motifs, indicating a role for VAV 1 as an adaptor protein linking cell surface receptors to downstream signaling proteins. VAV 1 is exclusively expressed in hematopoietic cells and plays a significant role in lymphocyte development and antigen receptor mediated activation of NFAT and NF(kappa)B, and in more delayed responses such as the production of cytokines, including IL-2, IL-3, IFN lambda, and TNF alpha. VAV 1 is also reported to activate JNK, p21-activated kinase (PAK) and PLC lambda, implicating its critical role in calcium mobilization, and cytoskeletal rearrangement. Activation of several cell surface 磷酸化鸟苷酸转换因子VAV1抗体receptors including integrins, immune response receptors, or growth factor receptors leads to phosphorylation of VAV 1 on tyrosine residues including tyrosine 160.

Vav1蛋白是特异于造血细胞表达的鸟苷酸转换因子,它参与了多种免疫细胞如T细胞,B细胞,巨噬细胞,自然杀伤性细胞等的胞内信号转导,发挥着重要作用. Vav1主要参与T细胞信号传导途径，传导信号激活钙流、细胞外信号调节激酶（ERK）以及转录因子NFκB。Vav1蛋白在T细胞生长发育、成熟T细胞激活、细胞因子合成及细胞骨架活动中发挥重要作用。