少突细胞髓磷脂糖蛋白抗体

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英文名称  Anti-Omgp

中文名称  少突细胞髓磷脂糖蛋白抗体

别    名  olyigodendrocyte myelin glycoprotein; OMG; OMGP; Oligodendrocyte-myelin glycoprotein; OMGP_HUMAN.

浓    度  1mg/1ml

规 格  0.1ml/100μg  0.2ml/200μg

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Cow

产品类型  一抗    

研究领域  神经生物学 信号转导 细胞凋亡  

蛋白分子量  predicted molecular weight: 43kDa

性    状  Lyophilized or Liquid

少突细胞髓磷脂糖蛋白抗体的主要功能是与抗原（包括外来的和自身的）相结合，从而有效地清除侵入机体内的微生物、寄生虫等异物，抗体（antibody）是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活，也可能无效但有时也会对机体造成病理性损害，如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生，对人体可造成危害。

免 疫 原  KLH conjugated synthetic peptide derived from human Omgp

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Oligodendrocyte myelin glycoprotein (OMG) is a glycosylphosphatidylinositol (GPI)-anchored CNS myelin protein, which is a potent inhibitor of neurite outgrowth in cultured neurons, and contributes significantly to the inhibitory activity associated with CNS myelin.

Function : Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

Subunit : Binds to RTN4R.

Subcellular Location : Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity : Oligodendrocytes and myelin of the central nervous system.

Post-translational modifications : O-glycosylated in its Ser/Thr-rich repeat domain (Potential).

少突细胞髓磷脂糖蛋白抗体Similarity : Contains 8 LRR (leucine-rich) repeats.

Contains 1 LRRNT domain.

Database links : UniProtKB/Swiss-Prot: P23515.2

OMgp也是髓鞘糖蛋白的一种，在发育期促进轴突生长,成熟期抑制轴突生长.其抑制作用主要由髓鞘来源的抑制分子的共同受体NgR介导,在神经营养因子受体p75NTR以及小GTP酶Rho等信号分子的共同参与下完成.