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英文名称 Anti-OCLN/Occludin
中文名称 紧密连接蛋白抗体
别 名 Occludin, Occludin-1; Occludin1; Occludin 1; FLJ08163; BLCPMG; FLJ18079; FLJ77961; FLJ94056; MGC34277; Occludin; OCLN; OCLN_HUMAN; Tight junction protein occludin.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig
产品类型 一抗
研究领域 细胞生物 免疫学 转录调节因子 细胞粘附分子
蛋白分子量 predicted molecular weight: 57kDa
性 状 Lyophilized or Liquid
紧密连接蛋白抗体的主要功能是与抗原(包括外来的和自身的)相结合,从而有效地清除侵入机体内的微生物、寄生虫等异物,抗体(antibody)是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活,也可能无效但有时也会对机体造成病理性损害,如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生,对人体可造成危害。
免 疫 原 KLH conjugated synthetic peptide derived from mouse OCLN C-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes an integral membrane protein which is located at tight junctions. This protein may be involved in the formation and maintenance of the tight junction. The possibility of several alternatively spliced products has been suggested but the full nature of these products has not been described.
Function : May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
Subunit : Interacts with TJP1/ZO1 and with VAPA.
Subcellular Location : Membrane; Multi-pass membrane protein. Cell junction, tight junction.
Tissue Specificity : Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
Post-translational modifications : Phosphorylated upon DNA damage, probably by ATM or ATR. Dephosphorylated by PTPRJ. May be phosphorylated by PKC during translocation to cell-cell contacts.
紧密连接蛋白抗体Similarity : Belongs to the ELL/occludin family.
Contains 1 MARVEL domain.
Database links : UniProtKB/Swiss-Prot: Q61146.1