促肾上腺皮质释放激素受体1抗体

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英文名称  Anti-CRHR1/CRFR1

中文名称  促肾上腺皮质释放激素受体1抗体

别    名  Corticotropin releasing hormone receptor variant 1h;CRF-RI; CRF 1; CRF R; CRF1; CRFR1; CRH R1h; CRF-R1; CRHR 1; CRHR; CRHR1; CRHR1f; Releasing hormone receptor 1; Seven transmembrane helix receptor; corticotropin releasing hormone receptor 1; Crhr1; Crhr; MGC124237; MGC124240; CRF-R; CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1; CRH-R1h; CRHR; CRHR1L; CRFR1_HUMAN.  

浓    度  1mg/1ml

规 格  0.1ml/100μg  0.2ml/200μg  

促肾上腺皮质释放激素受体1抗体概述：

B淋巴细胞在抗原的刺激下，能够分化、增殖形成具有针对这种抗原分泌特异性抗体的能力。B细胞的这种能力和量是有限的，不可能持续分化增殖下去，因此产生免疫球蛋白的能力也是极其微小的。将这种B细胞与非分泌型的骨髓瘤细胞融合形成杂交瘤细胞，再进一步克隆化，这种克隆化的杂交瘤细胞是既具有瘤细胞的无限分裂的能力，又具有产生特异性抗体的B淋巴细胞的能力。将这种克隆化的杂交瘤细胞进行培养或注入小鼠腹水内即可获得大量的高效、单一的特异性抗体。这种技术即称为单克隆抗体技术。

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat  

产品类型  一抗    

研究领域  肿瘤 细胞生物 免疫学 神经生物学 生长因子和激素 内分泌病  

蛋白分子量  predicted molecular weight: 48kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human CRHR1/CRFR1

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用   WB=  ELISA=  IP=  IHC-P=  IHC-F=  IF=

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants one of which is a non-coding read-through transcript with the neighboring gene MGC57346.

Function : Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subunit : Interacts (via N-terminal extracellular domain) with CRF and UCN.

Subcellular Location : Cell membrane; Multi-pass membrane protein.

Tissue Specificity : Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.

Post-translational modifications : C-terminal Ser or Thr residues may be phosphorylated.

促肾上腺皮质释放激素受体1抗体Similarity : Belongs to the G-protein coupled receptor 2 family.

Database links : UniProtKB/Swiss-Prot: P34998.1