您好,欢迎访问仪器信息网
注册
上海佳和生物科技有限公司

关注

已关注

已认证

粉丝量 0

当前位置: 佳和生物 > 抗体/抗原 > 补体C3cα 链片段1抗体

补体C3cα 链片段1抗体

供货周期: 现货
品牌: GenWay
规格: 0.1ml/100μg和0.2ml/200μg等规格
货号:
CAS号:
报价: ¥1
留言咨询
产品介绍

本公司是最专业补体C3cα 链片段1抗体供应商,提供补体C3cα 链片段1抗体的报价,补体C3cα 链片段1抗体咨询,技术服务,欢迎来电咨询选购。

英文名称  Anti-Complement C3c alpha' chain fragment 1

中文名称  补体C3cα 链片段1抗体

别    名  Acylation stimulating protein; ASP; C3; C3a anaphylatoxin; Complement C3 alpha chain; Complement C3; Complement C3 precursor; Complement component 3; Complement component C3; Complement factor 3; Plp; Complement C3c alpha' chain fragment 1; CO3_HUMAN.

浓    度  1mg/1ml

规 格  0.1ml/100μg  0.2ml/200μg  

补体C3cα 链片段1抗体概述:

B淋巴细胞在抗原的刺激下,能够分化、增殖形成具有针对这种抗原分泌特异性抗体的能力。B细胞的这种能力和量是有限的,不可能持续分化增殖下去,因此产生免疫球蛋白的能力也是极其微小的。将这种B细胞与非分泌型的骨髓瘤细胞融合形成杂交瘤细胞,再进一步克隆化,这种克隆化的杂交瘤细胞是既具有瘤细胞的无限分裂的能力,又具有产生特异性抗体的B淋巴细胞的能力。将这种克隆化的杂交瘤细胞进行培养或注入小鼠腹水内即可获得大量的高效、单一的特异性抗体。这种技术即称为单克隆抗体技术。

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human  

产品类型  一抗    

研究领域  细胞生物 免疫学 信号转导 G蛋白偶联受体 淋巴细胞  

蛋白分子量  predicted molecular weight: 23/181kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Complement C3c alpha' chain fragment 1

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500

(石蜡切片需做抗原修复)

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.

Function : C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.

Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Acylation stimulating protein (ASP): adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for GPR77. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of GPR77.

Subunit : C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with VSIG4. C3b interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 2 (HHV-2) envelope glycoprotein C; this interaction inhibits the activation of the complement system. Interacts with S.aureus immunoglobulin-binding protein sbi, this prevents interaction between C3dg and CR2. Interacts with S.aureus fib.

Subcellular Location : Secreted.

Tissue Specificity : Plasma. The acylation stimulating protein (ASP) is expressed in adiopocytes and released into the plasma during both the fasting and postprandial periods.

Post-translational modifications : C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g. C3a is further processed by carboxypeptidases to release the C-terminal arginine residue generating the acylation stimulating protein (ASP). Levels of ASP are increased in adipocytes in the postprandial period and by insulin and dietary chylomicrons.

Phosphorylation sites are present in the extracellular medium.

DISEASE : Defects in C3 are the cause of complement component 3 deficiency (C3D) [MIM:613779]. A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis.

Genetic variation in C3 is associated with susceptibility to age-related macular degeneration type 9 (ARMD9) [MIM:611378]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

Defects in C3 are a cause of susceptibility to hemolytic uremic syndrome atypical type 5 (AHUS5) [MIM:612925]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.

Note=Increased levels of C3 and its cleavage product ASP, are associated with obesity, diabetes and coronary heart disease. Short-term endurance training reduces baseline ASP levels and subsequently fat storage.

补体C3cα 链片段1抗体Similarity : Contains 1 anaphylatoxin-like domain.

Contains 1 NTR domain.

Database links : UniProtKB/Swiss-Prot: P01024.2


工商信息

企业名称

上海研生生化试剂有限公司

企业信息已认证

企业类型

信用代码

310112001038197

成立日期

2011-01-12

注册资本

100

经营范围

联系方式
补体C3cα 链片段1抗体由上海佳和生物科技有限公司为您提供,货号,规格: 0.1ml/100μg和0.2ml/200μg等规格,CAS号:,如您想了解更多关于补体C3cα 链片段1抗体价格、补体C3cα 链片段1抗体结构式、批发、用途等信息,欢迎咨询。除供应补体C3cα 链片段1抗体外,还可为您提供大鼠转甲状腺素蛋白(TTR)检测试剂盒 、Hs 683(人脑视神经胶质瘤细胞)、THLE-3(人肝上皮细胞)等试剂,公司有专业的客户服务团队,是您值得信赖的合作伙伴,佳和生物客户服务电话,售前、售后均可联系。
推荐产品
供应产品
相关品类

上海佳和生物科技有限公司

沟通底价

提交后,商家将派代表为您专人服务

获取验证码

{{maxedution}}s后重新发送

获取多家报价,选型效率提升30%
提交留言
点击提交代表您同意 《用户服务协议》 《隐私政策》 且同意关注厂商展位
联系方式:

公司名称: 上海佳和生物科技有限公司

公司地址: 上海莘庄工业区 联系人: 黄佳 邮编: 200070

友情链接:

仪器信息网APP

展位手机站