Ⅰ型补体受体抗体（C3b/C4b受体抗体）

我公司专业供应Ⅰ型补体受体抗体（C3b/C4b受体抗体）。了解更多关于的Ⅰ型补体受体抗体（C3b/C4b受体抗体）英文名称Ⅰ型补体受体抗体（C3b/C4b受体抗体）产品别名规格请看以下说明书。

英文名称  Anti-CR1/CD35

中文名称  Ⅰ型补体受体抗体（C3b/C4b受体抗体）

别    名  Complement receptor type 1; CR1; C3BR; C4BR; CD35; KN; C3-binding protein; CD35 antigen; complement component receptor 1; C3b/C4b receptor; Knops blood group antigen.

浓    度  1mg/1ml

规 格  0.1ml/100μg  0.2ml/200μg  

Ⅰ型补体受体抗体（C3b/C4b受体抗体）的功能：

抗体的主要功能是与抗原（包括外来的和自身的）相结合，从而有效地清除侵入机体内的微生物、寄生虫等异物，抗体（antibody）是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活，也可能无效但有时也会对机体造成病理性损害，如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生，对人体可造成危害。

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human  

产品类型  一抗    

研究领域  免疫学 细胞膜受体 淋巴细胞 t-淋巴细胞 b-淋巴细胞  

蛋白分子量  predicted molecular weight: 274kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human CR1/CD35

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.

Function : Mediates cellular binding of particles and immune complexes that have activated complement.

Subunit : Monomer.

Subcellular Location : Membrane; Single-pass type I membrane protein.

Similarity : Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.

Ⅰ型补体受体抗体（C3b/C4b受体抗体）Similarity : Belongs to the receptors of complement activation (RCA) family.

Contains 30 Sushi (CCP/SCR) domains.

CD35广泛分布于红细胞、粒细胞、单核细胞、肥大细胞、滤泡树突状细胞、肾小球足突细胞、B细胞及部分CD4+T细胞表面.CD35抗原又称为CR1或者C3b/C4b R，是一种分子量160-250kDa的C3b/C4b补体结合跨膜蛋白，主要用于滤泡树突状细胞标记和滤泡树突状细胞瘤的诊断。