我公司专业供应神经元突触膜胞外分泌调节蛋白1抗体。了解更多关于的神经元突触膜胞外分泌调节蛋白1抗体英文名称神经元突触膜胞外分泌调节蛋白1抗体产品别名规格请看以下说明书。
英文名称 Anti-RIM1/ABCA4
中文名称 神经元突触膜胞外分泌调节蛋白1抗体
别 名 ABCA4; CORD7; Rab-3-interacting molecule 1; Rab-3-interacting protein 2; RAB3 interacting protein 2; Rab3-interacting molecule 1; Rab3ip1; RAB3IP2; Regulating synaptic membrane exocytosis 1; Regulating synaptic membrane exocytosis protein 1; RIM 1; RIM; Rims1 (gene name); RIMS1; RIMS1_HUMAN; Serg1 (gene name); KIAA0340; MGC167823; MGC176677; Nbla00761.
浓 度 1mg/1ml
规 格 0.2ml/200μg
神经元突触膜胞外分泌调节蛋白1抗体的功能:
抗体的主要功能是与抗原(包括外来的和自身的)相结合,从而有效地清除侵入机体内的微生物、寄生虫等异物,抗体(antibody)是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活,也可能无效但有时也会对机体造成病理性损害,如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生,对人体可造成危害。
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep
产品类型 一抗
研究领域 细胞生物 神经生物学 细胞类型标志物 细胞膜蛋白
蛋白分子量 predicted molecular weight: 189kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human RIM1
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012].
Function : Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity.
Subunit : Binds RAB3A, RAB3B and RAB3D that have been activated by GTP-binding. Interacts with RAB3C, RAB10, RAB26 AND RAB37. Binds UNC13A. Interacts with BZRAP1/RIMBP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts with ERC1 (By similarity). Binds SNAP25, SYT1 and CACNA1B. Interaction with SYT1 is enhanced by calcium ions. Interaction with SNAP25 is weaker in the presence of calcium ions.
Subcellular Location : Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein (By similarity).
Tissue Specificity : Detected in brain and retina.
Post-translational modifications : Phosphorylated by BRSK1 (By similarity).
DISEASE : Defects in RIMS1 may be a cause of cone-rod dystrophy type 7 (CORD7) [MIM:603649]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.
Similarity : Contains 2 C2 domains.
Contains 1 FYVE-type zinc finger.
神经元突触膜胞外分泌调节蛋白1抗体Contains 1 PDZ (DHR) domain.
Contains 1 RabBD (Rab-binding) domain.
Database links : UniProtKB/Swiss-Prot: Q86UR5.1