Rap鸟嘌呤核苷酸交换因子2抗体

我公司专业供应Rap鸟嘌呤核苷酸交换因子2抗体。了解更多关于的Rap鸟嘌呤核苷酸交换因子2抗体英文名称，Rap鸟嘌呤核苷酸交换因子2抗体产品别名规格请看以下说明书。

英文名称  Anti-RAPGEF2/PDZ-GEF1

中文名称  Rap鸟嘌呤核苷酸交换因子2抗体

别    名  KIAA0313; Neural RAP guanine nucleotide exchange protein; nRap GEP; NRAPGEP; PDZ domain containing guanine nucleotide exchange factor 1; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ GEF1; PDZ-GEF1; PDZGEF1; RA GEF; RA-GEF; Rap guanine nucleotide exchange factor 2; Rapgef2; RPGF2_HUMAN.

浓    度  1mg/1ml

规 格  0.2ml/200μg

Rap鸟嘌呤核苷酸交换因子2抗体的功能：

抗体的主要功能是与抗原（包括外来的和自身的）相结合，从而有效地清除侵入机体内的微生物、寄生虫等异物，抗体（antibody）是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活，也可能无效但有时也会对机体造成病理性损害，如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生，对人体可造成危害。

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep  

产品类型  一抗    

研究领域  细胞生物 神经生物学 信号转导 G蛋白偶联受体 交换蛋白 G蛋白信号  

蛋白分子量  predicted molecular weight: 167kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human RAPGEF2 (501-600aa)

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 PDZ-GEF1 is a 1,499 amino acid cell membrane protein that functions as a guanine nucleotide exchange factor for Rap 1A, Rap 1B and Rap 2B GTPases. Expressed at highest levels in brain, PDZ-GEF1 is found at low levels in placenta, heart, lung and kidney, and undergoes post-translational phosphorylation following DNA damage. PDZ-GEF1 interacts with MAGI-2 and contains one Ras-GEF domain, a Ras-associating domain, one PDZ (DHR) domain, a single N-terminal Ras-GEF domain and a cyclic nucleotide-binding domain. The gene encoding PDZ-GEF1 maps to human chromosome 4q32.1.

Function : Guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B and Rap2B GTPases. Does not interact with cAMP or cGMP.

Subunit : Interacts with MAGI2.

Subcellular Location : Cell membrane (By similarity). Note=Associated with the synaptic plasma membrane

Tissue Specificity : Highest expression levels in brain. Lower expression levels in heart, kidney, lung, and placenta.

Post-translational modifications : Phosphorylation by PLK2 promotes its activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity : Contains 1 cyclic nucleotide-binding domain.

Contains 1 N-terminal Ras-GEF domain.

Contains 1 PDZ (DHR) domain.

Rap鸟嘌呤核苷酸交换因子2抗体Contains 1 Ras-associating domain.

Contains 1 Ras-GEF domain.

Database links : UniProtKB/Swiss-Prot: Q9Y4G8.1