维甲酸诱导蛋白3抗体

我公司专业供应维甲酸诱导蛋白3抗体。了解更多关于的维甲酸诱导蛋白3抗体英文名称，维甲酸诱导蛋白3抗体产品别名规格请看以下说明书。

英文名称  Anti-RAI3

中文名称  维甲酸诱导蛋白3抗体

别    名  G protein coupled receptor family C group 5 member A; G-protein coupled receptor family C group 5 member A; GPCR 5A; GPCR5A; Gprc 5a; Gprc5a; Orphan G protein coupling receptor PEIG 1; Orphan G protein coupling receptor PEIG1; Orphan G-protein-coupling receptor PEIG-1; RAI 3; RAI3_HUMAN; Raig 1; RAIG-1; Raig1; Retinoic acid induced 3; Retinoic acid induced gene 1 protein; Retinoic acid induced protein 3; Retinoic acid responsive; Retinoic acid responsive gene; Retinoic acid-induced gene 1 protein; Retinoic acid-induced protein 3.

浓    度  1mg/1ml

规 格  0.2ml/200μg

维甲酸诱导蛋白3抗体的功能：

抗体的主要功能是与抗原（包括外来的和自身的）相结合，从而有效地清除侵入机体内的微生物、寄生虫等异物，抗体（antibody）是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活，也可能无效但有时也会对机体造成病理性损害，如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生，对人体可造成危害。

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human  

产品类型  一抗    

研究领域  肿瘤 神经生物学 信号转导 细胞凋亡 G蛋白偶联受体 细胞分化 G蛋白信号  

蛋白分子量  predicted molecular weight: 40kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human RAI3 (1-33aa)

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 RAI3 is an transmembrane G-protein-coupled receptor that affects many essential biological processes including embryogenesis, cell growth, differentiation, and apoptosis. RAI3 may also be involved in maintaining homeostasis of epithelial cells. Retinoic acid receptors directly regulate RAI3 during its transcription in embryonal carcinoma differentiation. RAI3 expression is upregulated in most tumor cell lines that express mutant p53, suggesting that p53 interacts with the promoter of RAI3 and represses its expression at the beginning of apoptosis. RAI3 is a potential molecular target for diagnosing breast cancer, and selective suppression of signals from RAI3 may have a place in breast cancer treatments.

Function : Unknown. This G-protein coupled receptor could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. The comparable expression level in fetal lung and kidney with adult tissues suggests a possible role in embryonic development and maturation of these organs. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways.

Subcellular Location : Cell membrane. Cytoplasmic vesicle membrane. Localized in the plasma membrane and perinuclear vesicles.

Tissue Specificity : Expressed at high level in fetal and adult lung tissues. Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart.

维甲酸诱导蛋白3抗体Similarity : Belongs to the G-protein coupled receptor 3 family.

Database links : UniProtKB/Swiss-Prot: Q8NFJ5.2