神经元突触膜胞外分泌调节蛋白3抗体

本公司是最专业神经元突触膜胞外分泌调节蛋白3抗体供应商，提供神经元突触膜胞外分泌调节蛋白3抗体的报价，泛素样蛋白Sumo2/3抗体咨询，

英文名称  Anti-RIMS3

中文名称  神经元突触膜胞外分泌调节蛋白3抗体

别    名  NIM 3; NIM3; Rab 3 interacting molecule 3; Regulating synaptic membrane exocytosis 3; Regulating synaptic membrane exocytosis protein 3; RIMS 3; RIMS-3; RIM 3; RIM3; RIM3 gamma; RIMS3; RIMS3_HUMAN.

浓    度  1mg/1ml

规 格  0.2ml/200μg

神经元突触膜胞外分泌调节蛋白3抗体概述：

B淋巴细胞在抗原的刺激下，能够分化、增殖形成具有针对这种抗原分泌特异性抗体的能力。B细胞的这种能力和量是有限的，不可能持续分化增殖下去，因此产生免疫球蛋白的能力也是极其微小的。将这种B细胞与非分泌型的骨髓瘤细胞融合形成杂交瘤细胞，再进一步克隆化，这种克隆化的杂交瘤细胞是既具有瘤细胞的无限分裂的能力，又具有产生特异性抗体的B淋巴细胞的能力。将这种克隆化的杂交瘤细胞进行培养或注入小鼠腹水内即可获得大量的高效、单一的特异性抗体。这种技术即称为单克隆抗体技术。

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Zebrafish  

产品类型  一抗    

研究领域  细胞生物 神经生物学 细胞类型标志物  

蛋白分子量  predicted molecular weight: 33kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human RIMS3

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 Rab 3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis and functions in an inhibitory capacity, controlling the recruitment and pooling of secretory vesicles at the plasma membrane. The Rim (Rab 3 interacting molecule) family of proteins (Rim1, Rim2, Rim3 and Rim4) are multidomain adaptors that regulate Rab 3 activity and sub-sequent neurotransmitter release. Rim3, also known as RIMS3 (regulating synaptic membrane exocytosis 3) or NIM3, is a 308 amino acid member of the Rim family. Localized to the synapse and to cell junctions, Rim3 contains one C2 domain and is thought to play an important role in the regulation of synaptic membrane exocytosis. Rim3, a protein that may be phosphorylated upon DNA damage, is expressed throughout the body with highest levels present in brain tissue.

Function : RIMS3 belongs to a family of synaptic proteins that are essential for normal neurotransmitter release. It localizes primarily to neuronal dendrites and the postsynaptic densities, indicating that it may contribute to synapse transmission and plasticity.

Subunit : Binds PPFIA3 (By similarity). Does not bind RAB3.

神经元突触膜胞外分泌调节蛋白3抗体Subcellular Location : Cell junction, synapse.

Similarity : Contains 1 C2 domain.

Database links : UniProtKB/Swiss-Prot: Q9UJD0.1