c-Myc应答蛋白抗体

本公司是最专业c-Myc应答蛋白抗体供应商，提供c-Myc应答蛋白抗体的报价，泛素样蛋白Sumo2/3抗体咨询，

英文名称  Anti-RCL/c Myc responsive

中文名称  c-Myc应答蛋白抗体

别    名  c Myc responsive; c Myc responsive protein Rcl; C6orf108; Chromosome 6 open reading frame 108; Putative c Myc responsive; RCL_HUMAN.

浓    度  1mg/1ml

规 格  0.2ml/200μg

c-Myc应答蛋白抗体概述：

B淋巴细胞在抗原的刺激下，能够分化、增殖形成具有针对这种抗原分泌特异性抗体的能力。B细胞的这种能力和量是有限的，不可能持续分化增殖下去，因此产生免疫球蛋白的能力也是极其微小的。将这种B细胞与非分泌型的骨髓瘤细胞融合形成杂交瘤细胞，再进一步克隆化，这种克隆化的杂交瘤细胞是既具有瘤细胞的无限分裂的能力，又具有产生特异性抗体的B淋巴细胞的能力。将这种克隆化的杂交瘤细胞进行培养或注入小鼠腹水内即可获得大量的高效、单一的特异性抗体。这种技术即称为单克隆抗体技术。

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Dog, Pig, Horse, Rabbit  

产品类型  一抗    

研究领域  细胞生物 细胞周期蛋白 细胞分化  

蛋白分子量  predicted molecular weight: 19kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human RCL/c Myc responsive

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 This gene was identified on the basis of its stimulationby c-Myc protein. The latter is a transcription factor thatparticipates in the regulation of cell proliferation,differentiation, and apoptosis. The exact function of this gene isnot known but studies in rat suggest a role in cellularproliferation and c-Myc-mediated transformation. Two alternativetranscripts encoding different proteins have been described.[provided by RefSeq, Jul 2008].

Function : Catalyzes the cleavage of the N-glycosidic bond ofdeoxyribonucleoside 5'-monophosphates to yield deoxyribose5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside5'-monophosphates containing purine bases are preferred to thosecontaining pyrimidine bases (By similarity).

Subunit : Monomer and homodimer (By similarity).

Subcellular Location : Nucleus (By similarity). Cytoplasm.

Tissue Specificity : Expressed at low levels in brain, colon, lung,peripheral blood leukocytes, placenta, small intestine, and thymus.Expressed at high levels in heart, kidney, liver, skeletal muscleand spleen. Overexpressed in a significant proportion of breastcancers.

c-Myc应答蛋白抗体Similarity : Belongs to the deoxyribonucleoside 5'-monophosphateN-glycosidase family

Database links : UniProtKB/Swiss-Prot: O43598.1