血管生成素核糖核酸酶4抗体(肌萎缩性侧索硬化症蛋白)

本公司是最专业血管生成素核糖核酸酶4抗体(肌萎缩性侧索硬化症蛋白)供应商，提供血管生成素核糖核酸酶4抗体(肌萎缩性侧索硬化症蛋白)的报价，泛素样蛋白Sumo2/3抗体咨询，

英文名称  Anti-RNASE4/Angiogenin

中文名称  血管生成素核糖核酸酶4抗体(肌萎缩性侧索硬化症蛋白)

别    名  ALS9; AMYOTROPHIC LATERAL SCLEROSIS; ANG 1; ANG; ANG I; ANG1; ANGI; ANGI_HUMAN; Angiogenin; Angiogenin ribonuclease RNase A family, 5; Epididymis luminal protein 168; HEL168; MGC22466; MGC71966; Ribonuclease 5; Ribonuclease RNase A Family 5; RNase 5; RNASE4; RNASE5.

浓    度  1mg/1ml

规 格  0.1ml/100μg  0.2ml/200μg

血管生成素核糖核酸酶4抗体(肌萎缩性侧索硬化症蛋白)概述：

B淋巴细胞在抗原的刺激下，能够分化、增殖形成具有针对这种抗原分泌特异性抗体的能力。B细胞的这种能力和量是有限的，不可能持续分化增殖下去，因此产生免疫球蛋白的能力也是极其微小的。将这种B细胞与非分泌型的骨髓瘤细胞融合形成杂交瘤细胞，再进一步克隆化，这种克隆化的杂交瘤细胞是既具有瘤细胞的无限分裂的能力，又具有产生特异性抗体的B淋巴细胞的能力。将这种克隆化的杂交瘤细胞进行培养或注入小鼠腹水内即可获得大量的高效、单一的特异性抗体。这种技术即称为单克隆抗体技术。

抗体来源  Rabbit  

克隆类型  polyclonal

交叉反应  Human, Mouse, Rat, Pig, Horse

产品类型  一抗    

研究领域  肿瘤 心血管 细胞生物 信号转导 血管内皮细胞 细胞骨架 表观遗传学  

蛋白分子量  predicted molecular weight: 13/16kDa

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human RNASE4/Angiogenin

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍 May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.

Subcellular Location : Secreted.

Tissue Specificity : Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.

Similarity : Belongs to the pancreatic ribonuclease family.

血管生成素核糖核酸酶4抗体(肌萎缩性侧索硬化症蛋白)Involvement in disease; Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) . ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.