TNFAIP3特惠抗体

Goat Anti-TNFAIP3特惠抗体 antibody

From:RICKY

Catalog Number :RS-92803R

Quantity size : 0.1ml (dilute with pH 7.4 0.01 M PBS or antibody diluent )

Background:A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of

inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor

necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear

factor κ B (NFκB) gene expression. By inhibiting NFκB activation, A20 plays a critical

role in terminating NFκB responses to various stimuli. Although the C-terminal region of

A20 contains seven zinc finger domains, only four of these domains are required for in vitro

inhibition of TNF-induced NFκB activation. A20 also interacts with several other proteins,

such as TRAF2, TRAF6 and IkB kinase (IKK) γ protein, and can thereby inhibit cell death.

TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20.

Involved in the negative feedback regulation of signal transduction, A20 and A20-binding

proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases

Function:TNFAIP3特惠抗体

TNFAIP3 interacts with NAF1 and inhibits TNF induced NF kappa B dependent gene

expression by interfering with a RIP or TRAF2 mediated transactivation signal. It inhibits

programmed cell death, has a role in the function of the lymphoid system, and may contribute

to the in vivo effects of TNF.

Specificity : Anti-TNFAIP3 is a goat polyclonal antibody

specific for TNFAIP3 of Rabbit, Mouse, Rat

use for western blotting,elisa,immunoprecipitation and immunohistochemistry

– Protein G affinity chromatography purification, purity :>95%

– Isotype: IgG

– mol wt: 90 kDa

Application :TNFAIP3特惠抗体

– WB=1:100-500 ELISA=1:2000-5000 IP=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500

– not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user..

Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized

antibody is stable at room temperature for at least one month and for greater than a year

when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody,

the antibody is stable for at least six weeks at 2-4 ℃

Important Note: This product as supplied is intended for research use only, not for use in

human, therapeutic or diagnostic applications.