Anti-GRB2|生长因子受体结合蛋白2抗体

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Anti-GRB2|生长因子受体结合蛋白2抗体产品介绍：Growth factor receptor bound protein 2 (GRB2), also known as Ash protein, is a 24 kDa protein that contains a central Src homology (SH2) domain flanked by two SH3 domains. GRB2 is believed to be a regulatory subunit of signaling molecules whose activity is modulated by receptor binding. GRB2 associates with activated (tyrosine phosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNK through SH2 and SH3 domains. The SH3 domain binds to SOS, a guanine nucleotide exchange factor for Ras proteins. Endocytosis of activated EGFR requires the interaction of GRB2 with the GTP binding protein dynamin, a factor essential to the formation of endocytotic vesicle. It is ubiquitously expressed and several isoforms are produced by alternative splicing. On SDS PAGE, GRB2 has an apparent molecular weight of 28 kDa.

【产品名称】：Anti-GRB2|生长因子受体结合蛋白2抗体
【产品编号】：BYK-1465R
【规    格】：0.1ml/0.2ml
【相关标记】：Alexa Fluor 350   Alexa Fluor 488   Alexa Fluor 555   Alexa Fluor 647   AP   APC   Biotin   Cy3   Cy5   Cy5.5   Cy7   FITC   Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7   RBITC
【产品别名】：Mycoplasma Gallisepticum.
【浓    度】：1mg/1ml
【抗体来源】：Rabbit or Mouse or Goat
【克隆类型】：polyclonal or monoclonal
【产品类型】：一抗
【性    状】：Lyophilized or Liquid
【亚    型】：IgG
【纯化方法】：affinity purified by Protein A
【储 存 液】：0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
【产品应用】：not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
【保存条件】：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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