Anti-KLK7说明书|激肽释放酶7抗体

产品名称：Anti-KLK7说明书|激肽释放酶7抗体   

中文名称：激肽释放酶7抗体 

英文名称：Anti-KLK7  

产品编号：BYK-1966R  

产品别名：Chymotryptic stratum corneum; hK 7; hK7; hSCCE; hSCCE; Kallikrein 7 (chymotryptic stratum corneum); Kallikrein related peptidase 7; Kallikrein-7; Kallikrein7; KLK 7; Klk7; KLK7_HUMAN; Protease serine 6; PRSS 6; PRSS6; SCCE; Serine protease 6; Signal protein; Stratum corneum chymotryptic enzyme; Stratum corneum chymotryptic enzyme. 

本公司另供应其他标记：Alexa Fluor 350     Alexa Fluor 488    Alexa Fluor 555   Alexa Fluor 647    AP    APC    Biotin   Cy3    Cy5    Cy5.5   Cy7    FITC     Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7    RBITC.

产品规格：100ug/200ug

产品浓度：  1mg/1ml 

抗体来源：兔源、鼠源、其他 

克    隆：单克隆抗体、多克隆抗体

抗体类型：一抗 

性    状： 冻干粉或液体 

保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

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Anti-KLK7说明书|激肽释放酶7抗体产品介绍：

The human tissue Kallikrein gene family encodes 15 serine proteases. All Kallikreins share structural similarities including cysteine residues, a catalytic triad of His, Asp, and Ser residues, typically five coding exons and varied intron phases. Kallikreins are predominantly secreted as inactive zymogens prior to activation by cleavage of an N-terminal peptide and all function extracellularly. Kallikreins can be activated autocatalytically, via other Kallikreins, or additional proteases. While structurally similar, Kallikrein family members have distinct functions and have key roles in many physiological and pathological processes. Many human tissue Kallikreins also show promise as cancer biomarkers, which may facilitate earlier detection and characterization of many forms of cancer.
Kallikrein 7, also known as stratum corneum chymotryptic enzyme (SCCE) and PRSS6, is a chymotrypsin-like serine proteinase. Originally described from human skin as a serine protease involved in shedding of skin cells and remodeling if the skin, SCCE was later identified as Kallikrein 7. Kallikrein 7 is found at the highest levels in the skin, often complexed with the endogenous serpins SLPI or elafin and kallikrein 7 can be found complexed to a number of different proteinase inhibitors. In addition to skin, Kallikrein 7 has been found in the kidney, esophagus, neuronal tissues, amniotic fluid, saliva, breast milk, urine, synovial fluid, seminal plasma and serum. Kallikrein 7 has been reported to be decreased in the CSF of Alzheimer's patients and message levels of KLK7 were decreased in adenocarcinoma. In skin, overexpression of hK7 has been shown to cause a form of dermatitis and in psoriasis hK7 is expressed in higher levels than controls. The skin adhesive proteins corneodesmosin and desmocollin 1 have been reported to be substrates of Kallikrein 7, as is interleukin 1 and the insulin B-chain.