G蛋白结合蛋白3抗体

英文名称  Anti-SPG3A/Atlastin 

中文名称  G蛋白结合蛋白3抗体 

G蛋白结合蛋白3抗体别    名  AD FSP; atl1; ATLA1_HUMAN; Atlastin GTPase 1; Atlastin-1; Atlastin1; Brain specific GTP binding protein; Brain-specific GTP-binding protein; FSP1; GBP-3; GBP3; GTP-binding protein 3; Guanine nucleotide-binding protein 3; Guanylate binding protein 3; hGBP3; HSN1D; Spastic paraplegia 3 protein A; SPG 3A; SPG3; SPG3A. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Rabbit 

产品类型  一抗    

公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体，产品货期短、G蛋白结合蛋白3抗体品质保证、全国免邮，并提供抗体相应实验技术指导。

研究领域  细胞生物 神经生物学 结合蛋白 G蛋白偶联受体 G蛋白信号  

蛋白分子量  predicted molecular weight: 64kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human SPG3A/Atlastin (201-300aa) 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

G蛋白结合蛋白3抗体保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Atlastins are Golgi-localized, integral membrane proteins that function as GTPases. The Atlastin proteins, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance. Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration. HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness. Spastin, a microtubule (MT)-severing AAA ATPase, is a binding partner of Atlastin that is involved in membrane dynamics. This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development. Mutations in the Atlastin gene (SPG3A) account for approximately 10% of all autosomal dominant HSPs, while mutations in the Spastin gene (SPG4) account for almost 40%.

Function : GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.

Subunit : Homooligomer. Interacts (via N-terminal region) withMAP4K4 (via CNH regulatory domain). Interacts with REEP5, RTN3 andRTN4 (via the transmembrane region). Interacts with SPAST;interaction is direct. May interact with TMED2. Interacts withREEP1.

Anti-Phospho-Cytokeratin 17 (Ser44)  磷酸化细胞角蛋白17抗体 Multi-class antibodies 规格： 0.1ml

G蛋白结合蛋白3抗体Anti-CK19  细胞角蛋白19抗体 Multi-class antibodies 规格： 0.1ml

Anti-CK19  细胞角蛋白19抗体 Multi-class antibodies 规格： 0.1ml

Anti-CK20  细胞角蛋白20抗体 Multi-class antibodies 规格： 0.2ml

Anti-CK1/8/19  细胞角蛋白1/8/19抗体 Multi-class antibodies 规格： 0.1ml

Anti-CK2  细胞角蛋白2抗体 Multi-class antibodies 规格： 0.1ml

Anti-CK3  细胞角蛋白3抗体 Multi-class antibodies 规格： 0.1ml

Anti-CK4  细胞角蛋白4抗体 Multi-class antibodies 规格： 0.1ml

Anti-CK5  细胞角蛋白5抗体 Multi-class antibodies 规格： 0.1ml

Anti-CK7  细胞角蛋白7抗体 Multi-class antibodies 规格： 0.2ml

Anti-CK7  抗细胞角蛋白7抗体 Multi-class antibodies 规格： 0.2ml

Anti-CK10  细胞角蛋白10抗体 Multi-class antibodies 规格： 0.2ml

Anti-CK5+6  细胞角蛋白5+6抗体 Multi-class antibodies 规格： 0.1ml

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