监理蛋白抗体

英文名称  Anti-Supervillin 

中文名称  监理蛋白抗体 

监理蛋白抗体别    名  Archvillin; p205/p250; SVIL_HUMAN. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep 

产品类型  一抗    

公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体，产品货期短、监理蛋白抗体品质保证、全国免邮，并提供抗体相应实验技术指导。

研究领域  细胞生物 信号转导 表观遗传学  

蛋白分子量  predicted molecular weight: 248kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human Supervillin 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

监理蛋白抗体产品介绍 Supervillin is an F-actin-binding protein originally with two reported isoforms of 205/250 kDa. The longer isoform, named archvillin, is muscle-specific. Supervillin is a tightly bound peripheral membrane protein that is concentrated at sites of epithelial cell-cell adhesion. It contributes to cell-cell adhesion, motility regulation, and information transfer between cell compartments. The COOH-terminus of supervillin is homologous to villin/gelsolin but is not responsible for the tight binding to the actin cytoskeleton in vivo. The NH2-terminus contains functional nuclear localization sequences and F-actin and myosin II binding domains. It has been suggested that supervillin may mediate actin and myosin II filament organization at cholesterol-rich membrane domains. Supervillin has been identified as a transcriptional activator of the androgen receptor. Supervillin is found in many cells of several species, but is most abundant in muscle, bone marrow, thyroid gland, and salivary gland.

Function : Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adehesions involves binding to TRIP6 (By similarity). 

Subunit : Associates with F-actin. Interacts with NEB. Interacts with MYH9. Interacts with MYLK. Isoform 2 interacts with TRIP6. Isoform 2 interacts with DYNLT1 (By similarity). 

Anti-NF-KappaB p105  细胞核因子p50/k基因结合核因子抗体 Multi-class antibodies 规格： 0.1ml

监理蛋白抗体Anti-Phospho-NF-KappaB p105 (Ser927)  磷酸化细胞核因子p50/k基因结合核因子抗体 Multi-class antibodies 规格： 0.1ml

Anti-Phospho-NF-KappaB p105 (Ser933)  磷酸化细胞核因子p50/k基因结合核因子抗体 Multi-class antibodies 规格： 0.1ml

Anti-NGFR/p75NTR  神经生长因子受体抗体 Multi-class antibodies 规格： 0.1ml

Anti-NGF-beta  神经生长因子-β抗体 Multi-class antibodies 规格： 0.1ml

Anti-NGN3  神经元素3抗体 Multi-class antibodies 规格： 0.2ml

Anti-NGX6  鼻咽癌细胞相关基因6抗体 Multi-class antibodies 规格： 0.1ml

Anti-NHE1  钠氢通道蛋白抗体 Multi-class antibodies 规格： 0.2ml

Anti-NIK/MAPKKK14  NFkB诱导激酶抗体 Multi-class antibodies 规格： 0.2ml

Anti-NIS  钠碘转运体蛋白抗体 Multi-class antibodies 规格： 0.2ml

Anti-NIT2  NIT2蛋白抗体 Multi-class antibodies 规格： 0.2ml

Anti-Substance P Receptor  P物质受体抗体 Multi-class antibodies 规格： 0.1ml

Anti-NK-2R  神经激肽A受体/K物质受体抗体 Multi-class antibodies 规格： 0.1ml

Anti-NKA  神经激肽A抗体 Multi-class antibodies 规格： 0.2ml

Anti-NKB  神经激肽B抗体 Multi-class antibodies 规格： 0.2ml

Anti-NKG2A  NK细胞受体2A抗体 Multi-class antibodies 规格： 0.2ml

Anti-NKG2C  NK细胞受体2C抗体 Multi-class antibodies 规格： 0.2ml

Anti-NKG2D/CD314  NK细胞受体2D抗体 Multi-class antibodies 规格： 0.2ml

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