高分子量激肽原重链抗体

英文名称  Anti-Kininogen-1 light chain 

中文名称  高分子量激肽原重链抗体 

高分子量激肽原重链抗体别    名  Alpha 2 thiol proteinase inhibitor; HMW Kininogen light Chain; Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weight kininogen; HMWK; Ile-Ser-Bradykinin; Kallidin I; Kallidin II; Kininogen 1; KNG1; KNG1_HUMAN; Low molecular weight growth-promoting factor; Williams-Fitzgerald-Flaujeac 

规 格  0.2ml/200μg     

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Rabbit, Sheep

产品类型  一抗    

公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体，产品货期短、高分子量激肽原重链抗体品质保证、全国免邮，并提供抗体相应实验技术指导。

研究领域  心血管 细胞生物 免疫学  

蛋白分子量  predicted molecular weight: 28/70kDa 

性    状  Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human MPP4

亚    型  IgG

纯化方法  affinity purified by Protein A

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS,

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500

（石蜡切片需做抗原修复）

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

高分子量激肽原重链抗体产品介绍 This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]. 

Function : Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

GnRHR ELISA Kit  大鼠促性腺激素释放激素受体

AMPK ELISA Kit  大鼠磷酸化腺苷酸活化蛋白激酶

HSP47 ELISA Kit  大鼠热休克蛋白47

GC ELISA Kit  大鼠内源性糖皮质激素

CS ELISA Kit  大鼠柠檬酸合酶

L-LDH ELISA Kit   大鼠L-鼠乳酸脱氢酶

ACS ELISA Kit  大鼠脂酰辅酶A合成酶

CACT ELISA Kit  大鼠肉毒碱脂酰转移酶

pACCase ELISA Kit  大鼠磷酸化乙酰辅酶A羧化酶

MT ELISA Kit  大鼠金属硫蛋白

cTnT ELISA Kit  大鼠心肌特异性肌钙蛋白T

AChE ELISA Kit   大鼠乙酰胆碱酯酶

CDT ELISA Kit   大鼠糖缺失性转铁蛋白

TBA ELISA Kit   大鼠总胆汁酸

BMG/ Beta2-MG ELISA Kit  大鼠β2微球蛋白

RB高分子量激肽原重链抗体P ELISA Kit  大鼠视黄醇结合蛋白

GNRHR-Ab ELISA Kit  大鼠促性腺激素释放激素受体抗体

MBP ELISA Kit   大鼠主要碱性蛋白

ECP ELISA Kit  大鼠嗜酸性粒细胞阳离子蛋白

CaN ELISA Kit   大鼠钙调磷酸酶

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