英文名称 Anti-IL-6R Beta/CD130/gp130
中文名称 白细胞介素6受体β抗体IL-6Rβ
白细胞介素6受体β抗体IL-6Rβ别 名 Interleukin-6 receptor subunit beta; IL-6R-beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; CDw130; Oncostatin-M receptor subunit alpha; CD_antigen; CD130; GP130 RAPS; gp130 transducer chain; GP130-RAPS; IL6 ST; IL6R-beta; IL6ST.IL6R-beta.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat
产品类型 一抗
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研究领域 细胞生物 免疫学 信号转导 细胞膜受体
蛋白分子量 predicted molecular weight: 99kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human IL6R beta
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
白细胞介素6受体β抗体IL-6Rβ产品介绍 CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Function : Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
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GUSB/beta glucuronidase β葡萄糖醛酸苷酶抗体 规格 0.2ml
GYG1 糖原蛋白1抗体 规格 0.2ml
GYG2 糖原蛋白2抗体 规格 0.2ml
GYPB/CD235b 血型糖蛋白δ抗体 规格 0.2ml
GZMA/Granzyme A 颗粒酶A抗体 规格 0.2ml
GZMB/Granzyme B 颗粒酶B抗体 规格 0.1ml
H Cadherin/CDH13 心脏钙粘蛋白抗体 规格 0.2ml
H1N1 Hemagglutinin 1/HA probe 甲型流感病毒血凝素抗体 规格 0.2ml
H1N1 Hemagglutinin 1/Influenza A bp1 甲型流感病毒血凝素抗体 规格 0.2ml
H1N1 Hemagglutinin 2 甲型流感病毒血凝素抗体 规格 0.1ml
H1N1 白细胞介素6受体β抗体IL-6RβHemagglutinin 2 甲型流感病毒血凝素抗体 规格 0.1ml
H1N1 Matrix Protein 1 A型禽流感病毒H1N1蛋白抗体 规格 1ml
H1N1 matrix protein 2 甲型流感病毒M2抗体 规格 0.2ml
H1N1 Matrix Protein 2/Influenza A bp1 A型猪流感病毒H1N1-M2蛋白抗体 规格 0.2ml
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