英文名称 Anti-GLI1/Zfp5
中文名称 脑胶质瘤相关蛋白抗体（锌指蛋白5）
脑胶质瘤相关蛋白抗体（锌指蛋白5） 别 名 Gli 1; Gli1; Gli-1; GLI; GLI Kruppel family member 1; Glioma associated oncogene; Glioma associated oncogene homolog 1 (zinc finger protein); Oncogene GLI; Zfp 5; Zfp5; Zinc finger protein GLI 1; Zinc finger protein GLI1; GLI1_HUMAN.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse
产品类型 一抗
公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体，产品货期短、脑胶质瘤相关蛋白抗体（锌指蛋白5）品质保证、全国免邮，并提供抗体相应实验技术指导。
研究领域 肿瘤 细胞生物 神经生物学 信号转导 表观遗传学
蛋白分子量 predicted molecular weight: 118kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from hu GLI1/Zfp5
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脑胶质瘤相关蛋白抗体（锌指蛋白5）产品介绍 Gli1 is a member of the Kruppel family of zinc finger proteins. The Gli transcription factors constitute the final effectors of the Hedgehog signalling pathway, which is critical to vertebrate development. Gli1 may play a role in craniofacial and digital development, as well as development of the central nervous system and gastrointestinal tract. Ectopic activation of Gli proteins is linked to tumorigenesis. In addition, both the Ras and Transforming Growth Factor Beta pathways also stimulate and/or induce Gli1 and Gli2 activity independently of Hedgehog ligands.
Function : Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.
Subcellular Location : Cytoplasm. Nucleus. Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36. Phosphorylation by ULK3 may promote nuclear localization. Translocation to the nucleus is promoted by interaction with ZIC1.
Tissue Specificity : Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract.
Database links :
Entrez Gene: 517588 Cow
Entrez Gene: 2735 Human
Entrez Gene: 14632 Mouse
Omim: 165220 Human
SwissProt: P08151 Human
SwissProt: P47806 Mouse
Unigene: 632702 Human
Unigene: 391450 Mouse
GLI1是一种具有很强活性的转录激活因子，GLI1诱导G1/S细胞周期调节蛋白的表达从而促进细胞的增殖; 直接诱导抗凋亡因子Bcl-2的表达以抑制凋亡; 直接激活促进上皮组织向间质转化因子的转录从而加重了肿瘤的侵袭性。目前主要用于肿瘤及神经方面的研究。
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ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
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ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
脑胶质瘤相关蛋白抗体（锌指蛋白5）ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
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