促性腺激素释放激素受体抗体

英文名称  Anti-GnRHR 

中文名称  促性腺激素释放激素受体抗体 

促性腺激素释放激素受体抗体别    名  Gonadotropin-releasing hormone receptor; GH1; Lhrhr; GnRH receptor; gnrh-r; GnRHR; GNRHR1; Gonadotropin releasing hormone receptor; GRHR; leutinizing-releasing hormone receptor; lh-rh; LHRHR; LRHR; luteinizing hormone releasing hormone receptor; GNRHR_HUMAN 

浓    度  1mg/1ml 

规 格  0.1ml/100μg  0.2ml/200μg     

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep

产品类型  一抗    

公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体，产品货期短、促性腺激素释放激素受体抗体品质保证、全国免邮，并提供抗体相应实验技术指导。

研究领域  信号转导 生长因子和激素  

蛋白分子量  predicted molecular weight: 36kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human GnRHR 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Gonadotropin Releasing Hormone (GnRH) is down-regulated by hCG and believed to be an autocrine factor that regulates the ovary. The Gonadotropin Releasing Hormone Receptor (GnRHR) is synthesized in the pituitary gland. Activin A has been shown to stimulate the synthesis of GnRHR, illustrating a possible mechanism for the modulation of gonadotropin responsiveness to GnRH.

Function : Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.

Subcellular Location : Cell membrane; Multi-pass membrane protein.

Tissue Specificity : Pituitary, ovary, testis, breast and prostate but not in liver and spleen.

DISEASE : Hypogonadotropic hypogonadism 7 with or without anosmia (HH7) [MIM:146110]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and 促性腺激素释放激素受体抗体sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note=The disease is caused by mutations affecting the gene represented in this entry. 

Fertile eunuch syndrome (FEUNS) [MIM:228300]: Mild phenotypic form of HH going with the presence of normal testicular size and some degree of spermatogenesis. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity : Belongs to the G-protein coupled receptor 1 family.

Database links : UniProtKB/Swiss-Prot: P30968.1 

信号传导（Signaling Intermediates）

Grb2是生长因子受体结合蛋白2,又称Ash蛋白。该蛋白参与细胞内各种受体激活后的下游调节。能够直接与激活的表皮生长因子受体磷酸化的酪氨酸结合,参与EGF受体介导的信号转导, 属SH蛋白.

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

促性腺激素释放激素受体抗体ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

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