英文名称 Anti-EGF(mouse)
中文名称 表皮生长因子抗体(小鼠)
表皮生长因子抗体(小鼠)别 名 Beta urogastrone; Epidermal Growth Factor; Pro epidermal growth factor; URG; Urogastrone; EGF_MOUSE.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Mouse
产品类型 一抗
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研究领域 肿瘤 细胞生物 免疫学
蛋白分子量 predicted molecular weight: 6/130kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from mouse EGF C-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The 表皮生长因子抗体(小鼠)lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Epidermal growth factor (EGF) has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells. The EGF precursor is believed to exist as a membrane bound molecule which is proteolytically cleaved to generate the 53 amino acid peptide hormone that stimulates cells to divide. EGF exerts its actions by binding to the EGFR, a 170 kDa protein.
Epidermal growth factor (EGF) is a key growth factor regulating cell survival. Through its binding to cell surface receptors, EGF activates an extensive network of signal transduction pathways that include activation of the PI3K/AKT, RAS/ERK and JAK/STAT pathways. Because of its key role in driving the proliferation of cells, EGFR is a target of several anti-cancer drugs currently in development.
Function : EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).
Subunit : Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD). Interacts with RHBDF2.
Subcellular Location : Membrane; Single-pass type I membrane protein.
Similarity : Contains 9 EGF-like domains.
Contains 8 LDL-receptor class B repeats.
Database links : UniProtKB/Swiss-Prot: P01132.2
表皮生长因子是一种小肽,由53个氨基酸残基组成, 是类EGF大家族的一个成员,是一种多功能的生长因子,在体内体外都对多种组织细胞有强烈的促分裂作用。EGF同应答细胞表面的特异受体结合,一旦结合,便促进受体二聚化并使细胞质位点磷酸化。被激活的受体至少可与5种具有不同信号序列的蛋白结合,进行信号转导,在翻译水平上对蛋白质的合成起调节作用。此外EGF可提高细胞内DNA拓扑异构酶活性,也可促进一些与增殖有关的基因表达,如myc 、fos等。
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ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
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ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
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ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
表皮生长因子抗体(小鼠)ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
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企业名称
上海研生生化试剂有限公司
企业信息已认证
企业类型
信用代码
310112001038197
成立日期
2011-01-12
注册资本
100
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上海研生实业有限公司
公司地址
上海市漕宝路66号20F
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