磷酸化细胞外信号调节激酶5抗体

英文名称  Anti-phospho-ERK5( Ser731+Thr733) 

中文名称  磷酸化细胞外信号调节激酶5抗体 

磷酸化细胞外信号调节激酶5抗体别    名  MAPK7(phospho S731/T733); MAPK7; Big MAP kinase 1; BMK 1; BMK 1 kinase; BMK1; BMK1 Kinase; EC 2.7.11.24; ERK 4; ERK 5; ERK5 ERK4; Extracellular Signal Regulated Kinase 5; MAPK 7; Mitogen Activated Protein Kinase 7; PRKM 7; PRKM7; MK07_HUMAN. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg     

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Cow, Rabbit

产品类型  一抗  磷酸化抗体   

公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体，产品货期短、磷酸化细胞外信号调节激酶5抗体品质保证、全国免邮，并提供抗体相应实验技术指导。

研究领域  肿瘤 免疫学 信号转导 转录调节因子 激酶和磷酸酶  

蛋白分子量  predicted molecular weight: 90kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated Synthesised phosphopeptide derived from human ERK5 around the phosphorylation site of Ser731+Thr733 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Extracellular signal related protein kinase 5/big mitogen activated protein kinase 1 (ERK5/BMK1) is an 88 kDa member of the MAP kinase superfamily that becomes fully activated when phosphorylated on threonine 218 and tyrosine 220 by MEK5. ERK5 is activated in response to certain growth factors and bioactive peptides, however the upstream activators are distinct from those that activate ERK1 and 2.

Function : Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression.

Subunit : Interacts with MAP2K5. Forms oligomers. Interacts with MEF2A, MEF2C and MEF2D; the interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D. Interacts with SGK1.

Subcellular Location : Cytoplasm. Nucleus. Note=Translocates to the nucleus upon activation.

Tissue Specificity : Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver.

Post-translational modifications : Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme. Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.

Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Database links : UniProtKB/Swiss-Prot: Q13164.2

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磷酸化细胞外信号调节激酶5抗体

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ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

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ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

磷酸化细胞外信号调节激酶5抗体ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

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