磷酸化埃兹蛋白抗体

英文名称  Anti-Phospho-Ezrin (Thr567) 

中文名称  磷酸化埃兹蛋白抗体 

磷酸化埃兹蛋白抗体别    名  Ezrin (phospho T567); Ezrin (phospho Thr567); p-Ezrin (phospho T567); CVIL; CVL; cytovillin 2 ; Cytovillin ; DKFZp762H157; FLJ26216; MGC1584; p81; VIL 2 ; VIL2; Villin 2; Villin2; EZRI_HUMAN. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg     

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig

产品类型  一抗  磷酸化抗体   

公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体，产品货期短、磷酸化埃兹蛋白抗体品质保证、全国免邮，并提供抗体相应实验技术指导。

研究领域  肿瘤 信号转导  

蛋白分子量  predicted molecular weight: 64kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated Synthesised phosphopeptide derived from human Ezrin around the phosphorylation site of Thr567 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

Function : Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

Subunit : Interacts with MPP5 and SLC9A3R2. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts with MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1 and TMEM8B. Interacts (when phosphorylated) with FES/FPS.

Subcellular Location : Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes. Microvillar peripheral membrane protein (cytoplasmic side).

磷酸化埃兹蛋白抗体Tissue Specificity : Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.

Post-translational modifications : Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-bindin.

Similarity : Contains 1 FERM domain.

Database links : UniProtKB/Swiss-Prot: P15311.4

信号传导（Signaling Intermediates）

    目前研究发现Ezrin蛋白与维持细胞的形状、极性、生长运动以及信号转导方面发挥重要作用，该蛋白与肿瘤的侵袭、转移有关。

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

磷酸化埃兹蛋白抗体ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

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