内皮细胞受体蛋白酪氨酸激酶A抗体（肿瘤坏死因子α诱导蛋白4）

英文名称  Anti-EphA1/Ephrina1/Ephrin A1  

中文名称  内皮细胞受体蛋白酪氨酸激酶A抗体（肿瘤坏死因子α诱导蛋白4） 

内皮细胞受体蛋白酪氨酸激酶A抗体（肿瘤坏死因子α诱导蛋白4）别    名  Ephrin-A1; EPH-related receptor tyrosine kinase ligand 1; LERK-1; Immediate early response protein B61; Tumor necrosis factor alpha-induced protein 4; TNF alpha-induced protein 4; Ephrin-A1, secreted form; EFNA1_HUMAN. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg  0.2ml/200μg     

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat

产品类型  一抗    

公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体，产品货期短、内皮细胞受体蛋白酪氨酸激酶A抗体（肿瘤坏死因子α诱导蛋白4）品质保证、全国免邮，并提供抗体相应实验技术指导。

研究领域  肿瘤 心血管 神经生物学 激酶和磷酸酶 细胞表面分子  

蛋白分子量  predicted molecular weight: 19/22kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human Ephrin A1  

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

内皮细胞受体蛋白酪氨酸激酶A抗体（肿瘤坏死因子α诱导蛋白4） not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 

Function : Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. 

Subunit : Monomer. Homodimer. Forms heterodimers with EPHA2. Binds to the receptor tyrosine kinases EPHA2, EPHA3, EPHA4, EPHA5, EPHA6 and EPHA7. Also binds with low affinity to EPHA1.

Subcellular Location : Cell membrane; Lipid-anchor, GPI-anchor. 

Ephrin-A1, secreted form: Secreted.

Tissue Specificity : Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).

Post-translational modifications : Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.

Similarity : Belongs to the ephrin family. 

Contains 1 ephrin RBD (ephrin receptor-binding) domain. 

Database links : UniProtKB/Swiss-Prot: Q9Y258.1

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

内皮细胞受体蛋白酪氨酸激酶A抗体（肿瘤坏死因子α诱导蛋白4）ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

ANG-2 (Rabbit Angiopoietin 2) ELISA Kit  兔血管生成素2

更多内皮细胞受体蛋白酪氨酸激酶A抗体（肿瘤坏死因子α诱导蛋白4）价格、 内皮细胞受体蛋白酪氨酸激酶A抗体（肿瘤坏死因子α诱导蛋白4）批发价、 内皮细胞受体蛋白酪氨酸激酶A抗体（肿瘤坏死因子α诱导蛋白4）品牌、厂家及抗体详细说明书，都可跟我们销售人员索取。