英文名称 Anti-E2F6
中文名称 转录因子E2F6抗体
转录因子E2F6抗体别 名 E2F 6; E2F binding site modulating activity protein; E2F transcription factor 6; E2F transcription factor 6 isoform 1; EMA; MGC111545; Transcription factor E2F6; E2F6_HUMAN.
浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat
产品类型 一抗
公司全程供应Abcam、CST、Abnova、BD、GeneTex、Proteintech、SB、Abgent、AbFrontier、AnaSpec、Agrisera、Alomone、Epitomics、Active Motif、Assaybiotech、Biorbyt、BioVision、Bender、CaymanChemical、Covance、ChromoTek、Enzo、eBioscience、Glen Research、MBL、ProSci、PeproTech、Swant、Vector等品牌公司抗体,产品货期短、转录因子E2F6抗体品质保证、全国免邮,并提供抗体相应实验技术指导。
研究领域 免疫学 转录调节因子
蛋白分子量 predicted molecular weight: 32kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human E2F6 N-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The E2F6 gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses.
Function : Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Subunit : Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, 转录因子E2F6抗体MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.
Subcellular Location : Nucleus.
Tissue Specificity : Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.
Similarity : Belongs to the E2F/DP family.
Database links : UniProtKB/Swiss-Prot: O75461.1
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ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
转录因子E2F6抗体ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
ANG-2 (Rabbit Angiopoietin 2) ELISA Kit 兔血管生成素2
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企业名称
上海研生生化试剂有限公司
企业信息已认证
企业类型
信用代码
310112001038197
成立日期
2011-01-12
注册资本
100
经营范围
上海研生实业有限公司
公司地址
上海市漕宝路66号20F
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