内皮抑素/内皮他丁抗体

英文名称  Anti-Endostatin/COL18A1 

中文名称  内皮抑素/内皮他丁抗体 

内皮抑素/内皮他丁抗体别    名  Alpha 1 collagen type 18 (XVIII)(COL18A1); Alpha 1 type XVIII collagen; COL18A1; Collagen alpha 1(XVIII) chain; Collagen type XVIII alpha 1; FLJ27325; KNO; MGC74745; COL18A1; COIA1_HUMAN. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg  0.2ml/200μg     

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat

产品类型  一抗    

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研究领域  肿瘤 免疫学 生长因子和激素  

蛋白分子量  predicted molecular weight: 20kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human Endostatin C-terminus 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene.

内皮抑素/内皮他丁抗体Function : COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. 

Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.

Subcellular Location : Secreted, extracellular space, extracellular matrix.

Tissue Specificity : Present in multiple organs with highest levels in liver, lung and kidney.

Post-translational modifications : Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

DISEASE : Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.

Similarity : Belongs to the multiplexin collagen family.

Contains 1 FZ (frizzled) domain.

Contains 1 TSP N-terminal (TSPN) domain.

Database links : 

UniProtKB/Swiss-Prot: P39060.5 

Entrez Gene: 1306 Human 

Entrez Gene: 80781 Human 

Entrez Gene: 12819 Mouse 

Entrez Gene: 12822 Mouse 

Entrez Gene: 85251 Rat 

Omim: 120328 Human 

SwissProt: P39059 Human 

SwissProt: P39060 Human 

内皮抑素(endostatin)又称胶原蛋白18A1，是目前较理想的血管形成抑制因子,它通过抑制肿瘤血管生成达到阻止肿瘤生长和转移的目的.当前，血管内皮抑制素主要用于抑止肿瘤血管的生长方面的研究。 

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