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桥粒芯糖蛋白2抗体，Anti-Desmoglein 2

供货周期：一周

品牌： Abcam

规格： 0.2ml/200μg

货号：

CAS号：

报价： ¥1

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产品介绍

桥粒芯糖蛋白2抗体英文名称 Anti-Desmoglein 2

中文名称桥粒芯糖蛋白2抗体

别名 ARVC 10; ARVC10; ARVD 10; ARVD10; CDHF5; Desmoglein2; Desmoglein-2; DSG2; HDGC; HDGC included; DSG2_HUMAN; Desmoglein-2; Cadherin family member 5; HDGC.

公司桥粒芯糖蛋白2抗体应用于医学免疫学、动物免疫学、分子生物学、生物化学、临床医学、检验医学、动物医学、药学、理工、农学、环境学等生命科学密切相关的专业。

浓度 1mg/1ml

规格 0.1ml/100μg 0.2ml/200μg

抗体来源 Rabbit

克隆类型 polyclonal

交叉反应 Human, Mouse, Rat, Dog, Horse

产品类型一抗

研究领域心血管免疫学信号转导细胞粘附分子

蛋白分子量 predicted molecular weight: 118kDa

性状 Lyophilized or Liquid

免疫原 KLH conjugated synthetic peptide derived from human Desmoglein 2 (121-170aa)

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

桥粒芯糖蛋白2抗体产品介绍 Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines.

Function : Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Subcellular Location : Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Tissue Specificity : All of the tissues tested and carcinomas.

DISEASE : Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10) [MIM:610193]; also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.

Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB) [MIM:612877]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Similarity : Contains 4 cadherin domains.

Database links : UniProtKB/Swiss-Prot: Q14126.2

【存储要求】连续使用时4°C存储，保质期六个月；桥粒芯糖蛋白2抗体期存储时建议分装为10ul以上小包装-20°C存储，并避免反复冻融，保质期一年。

实验的用途：

1）WB：Western Blotting 免疫印迹

2）IH：Immunohistochemistry 免疫组化

3）IH(P)：Immunohistochemistry Parraffin sections 免疫组化(石蜡)

4）IH(F)：Immunohistochemistry Frozen sections 免疫组化(冰冻)

5）IC：Immunocytochemistry 免疫细胞化学

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成立日期

2013-03-11

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桥粒芯糖蛋白2抗体，Anti-Desmoglein 2由上海基免实业有限公司为您提供，货号，规格：0.2ml/200μg ，CAS号：，如您想了解更多关于桥粒芯糖蛋白2抗体，Anti-Desmoglein 2价格、桥粒芯糖蛋白2抗体，Anti-Desmoglein 2结构式、批发、用途等信息，欢迎咨询。除供应桥粒芯糖蛋白2抗体，Anti-Desmoglein 2外，还可为您提供昆虫蜕皮激素(Ecdysone)检测试剂盒、呕吐毒素(vomitoxin)检测试剂盒、鸭免疫球蛋白M(IgM)检测试剂盒等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海基免客户服务电话，售前、售后均可联系。

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