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当前位置: 上海基免 > 生物分子 > 肌营养蛋白α抗体,Anti-DRP3/Dystrobrevin alpha

肌营养蛋白α抗体,Anti-DRP3/Dystrobrevin alpha

供货周期: 7天
品牌: Abcam
型号: 0.2ml/200μg
货号:
报价: ¥1
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产品介绍
肌营养蛋白α抗体英文名称  Anti-DRP3/Dystrobrevin alpha 
中文名称  肌营养蛋白α抗体 
别    名  Dystrobrevin alpha; DRP3; DTN; DTNA; Dystrophin related protein 3; FLJ96209; LVNC1; OTTHUMP00000163154; OTTHUMP00000163155; D18S892E. 
公司肌营养蛋白α抗体应用于医学免疫学、动物免疫学、分子生物学、生物化学、临床医学、检验医学、动物医学、药学、理工、农学、环境学等生命科学密切相关的专业。   
浓    度  1mg/1ml 
规 格  0.2ml/200μg          
抗体来源  Rabbit  
克隆类型  polyclonal 
交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit   
产品类型  一抗    
研究领域  细胞生物 免疫学 神经生物学  
蛋白分子量  predicted molecular weight: 63kDa 
性    状  Lyophilized or Liquid 
免 疫 原  KLH conjugated synthetic peptide derived from human Dystrobrevin alpha/DRP3 
亚    型  IgG 
纯化方法  affinity purified by Protein A 
储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 
产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 
(石蜡切片需做抗原修复) 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
肌营养蛋白α抗体产品介绍 Dystrobrevin alpha belongs to the dystrobrevin subfamily of the dystrophin family. It is a component of the dystrophin associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha and beta dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin alpha may be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. Mutations in Dystrobrevin alpha are associated with left ventricular noncompaction with congenital heart defects.
Function : Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration .
Subunit : Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.
Subcellular Location : Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
Tissue Specificity : Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
Post-translational modifications : Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
Similarity : Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Database links : UniProtKB/Swiss-Prot: Q14195.1 (humna) 
UniProtKB/Swiss-Prot: Q62188.1 (mouse)
【存储要求】连续使用时4°C存储,保质期六个月;肌营养蛋白α抗体期存储时建议分装为10ul以上小包装-20°C存储,并避免反复冻融,保质期一年。
实验的用途:
1)WB:Western Blotting 免疫印迹
2)IH:Immunohistochemistry 免疫组化
3)IH(P):Immunohistochemistry Parraffin sections 免疫组化(石蜡)
4)IH(F):Immunohistochemistry Frozen sections 免疫组化(冰冻)
5)IC:Immunocytochemistry 免疫细胞化学
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上海基免实业有限公司

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310116002801941

成立日期

2013-03-11

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