DLX4抗体

DLX4抗体英文名称  Anti-DLX4 

中文名称  DLX4抗体 

别    名  Beta protein 1; distal-less homeobox 4; DLX4; DLX4_HUMAN; DLX7; DLX8; Homeobox protein DLX-4; Homeobox protein DLX-7; Homeobox protein DLX-8; Homeobox protein DLX4. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg          

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Cow, Rabbit   

产品类型  一抗    

研究领域  染色质和核信号 转录调节因子  

蛋白分子量  predicted molecular weight: 26kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human DLX4 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

DLX4抗体产品介绍 Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008].

Function : May play a role in determining the production of hemoglobin S. May act as a repressor.

Subcellular Location : Nucleus (Potential).

Tissue Specificity : Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver.

Similarity : Belongs to the distal-less homeobox family.

Contains 1 homeobox DNA-binding domain.

Database links : UniProtKB/Swiss-Prot: Q92988.4

DLX4基因的表达异常与乳腺癌、结肠癌以及白血病的发生有关.与AML-急性髓系白血病有一定的相关性，DLX4 在急性髓系白血病有高表达，在急性淋巴细胞白血病中无表达，可作为AML的一种分子标志，用于两者的鉴别参考。