β葡聚糖受体抗体

β葡聚糖受体抗体英文名称  Anti-DECTIN-1/CLECSF12/beta Glucan Receptor 

中文名称  β葡聚糖受体抗体 

别    名  Dectin1; Dectin-1; Dectin 1; CLECSF12; C-type lectin domain family 7 member A; beta Glucan Receptor; Beta GR; BGR; C type calcium dependent carbohydrate recognition domain lectin superfamily member 12; Clec7a; CANDF4; DECTIN1; CLEC7A protein; Clecsf12; Dectin 1; DECTIN 1 receptor; Dectin1; Dendritic cell associated C type lectin 1; Lectin like receptor 1; beta Glucan Receptor; Putative transmembrane protein dectin 1; CLC7A_HUMAN. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg  0.2ml/200μg          

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat   

产品类型  一抗    

研究领域  细胞生物 免疫学 淋巴细胞  

蛋白分子量  predicted molecular weight: 28kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human Dectin-1 C-terminus 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

β葡聚糖受体抗体产品介绍 This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq].

Function : Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity).

Subunit : Homodimer (By similarity). Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens (By similarity).

Subcellular Location : Cell membrane; Single-pass type II membrane protein (By similarity).

Tissue Specificity : Detected in dendritic cells, in paracortical and medullary regions of lymph nodes, and in spleen red pulp and white pulp.

Post-translational modifications : on tyrosine residues in response to glucan binding (By similarity).

Similarity : Contains 1 C-type lectin domain.

Database links : UniProtKB/Swiss-Prot: Q9BXN2.1

β-葡聚糖受体是一种非调理素依赖性受体,可在免疫反应早期,在清除衰老细胞和防御感染方面发挥重要作用,进而实现其抗肿瘤、抗感染等生物学效应。