DYDC1蛋白抗体

DYDC1蛋白抗体英文名称  Anti-DYDC1 

中文名称  DYDC1蛋白抗体 

别    名  DPY30 domain-containing protein 1; DPY30D1; DYDC1; DYDC1_HUMAN; RSD 9; RSD9. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg          

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep   

产品类型  一抗    

研究领域  细胞生物 免疫学 发育生物学 神经生物学  

蛋白分子量  predicted molecular weight: 21kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human DYDC1 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

DYDC1蛋白抗体产品介绍 The Dumpy-30 (DPY-30) protein was first described in C. elegans, in which it is involved in dosage compensation of sex chromosomes. Conserved from yeast to humans, the DPY-30 family is involved in gene expression and chromatin modification, specifically histone methylation. DPY-30 and closely related proteins contain a short motif that is related to the dimerization motif in the regulatory subunit of protein kinase A (PKA), which consists of two ?helices that form a four-helix bundle during dimerization. As a member of the DPY-30 family, DYDC1 (DPY30 domain-containing protein 1), also known as DPY30D1 and RSD9, is a 177 amino acid protein that binds to Endophilin III and plays a crucial role during acrosome biogenesis. DYDC1 is specifically expressed in brain and testis and accumulates in the acrosome area during spermatogenesis. Knockdown of DYDC1 mRNA results in disruption of acrosome formation and spermatid differentiation.

Function : Plays a crucial role during acrosome biogenesis. 

Subunit : Interacts with SH3GL3. 

Tissue Specificity : Brain and testis. Accumulates during late stage of spermiogenesis.

Similarity : Belongs to the dpy-30 family. 

Database links : UniProtKB/Swiss-Prot: Q8WWB3.1