白喉酰胺生物合成样蛋白2抗体

白喉酰胺生物合成样蛋白2抗体英文名称  Anti-DPH2 

中文名称  白喉酰胺生物合成样蛋白2抗体 

别    名  Diphthamide biosynthesis like protein 2; Diphthamide biosynthesis protein 2; Diphthamide biosynthesis protein 2 homolog like 2; Diphthamide biosynthesis protein 2 homolog-like 2; Diptheria toxin resistance protein required for diphthamide biosynthesis like 2; Diptheria toxin resistance protein required for diphthamide biosynthesis like 2 S. cerevisiae ; DPH 2; DPH2; DPH2 homolog; DPH2 homolog S. cerevisiae; DPH2 like 2; DPH2 like 2 S. cerevisiae; DPH2-like 2; DPH2_HUMAN; DPH2L2; HsDph2; OTTHUMP00000010007; Protein DPH2 homolog. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg          

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep   

产品类型  一抗    

研究领域  肿瘤 细胞生物 免疫学 细胞膜受体  

蛋白分子量  predicted molecular weight: 52kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human DPH2 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

白喉酰胺生物合成样蛋白2抗体产品介绍 DPH2 (diphthamide biosynthesis protein 2), also known as DPH2L2, is a 489 amino acid protein that shows strong expression in skeletal muscle; moderate expression in heart, small intestine, liver, pancreas, testis and colon; and lesser expression in brain, placenta, kidney, spleen, thymus, prostate, ovary and lymphocytes. DPH2 interacts with DPH1 and, functioning together as a dimer or multimer, DPH1 and DPH2 may participate in diphthamide biosynthesis. Diphthamide is a posttranslationally modified histidine residue which occurs in EF-2 (elongation factor 2) and targets diphtheria toxin ADP-ribosylation. The loss of DPH2 in Saccharomyces cerevisiae is believed to suppress zymocicity. Two transcript variants encoding different isoforms have been found for this gene.

Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.

Tissue specificity:

Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, speen, thymus, prostate, ovary and lymphocytes.

Function : Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (By similarity). 

Subunit : Interacts with DPH1 (By similarity). 

Tissue Specificity : Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, speen, thymus, prostate, ovary and lymphocytes. 

Similarity : Belongs to the DPH1/DPH2 family. DPH2 subfamily. 

Database links : UniProtKB/Swiss-Prot: Q9BQC3.1