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当前位置: 上海基免 > 生物分子 > 磷酸化D酪氨酸激酶衰减蛋白1抗体,Anti-phospho-DOK1(Tyr362)

磷酸化D酪氨酸激酶衰减蛋白1抗体,Anti-phospho-DOK1(Tyr362)

供货周期: 7天
品牌: Abcam
型号: 0.1ml/100μg
货号:
报价: ¥1
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产品介绍
磷酸化D酪氨酸激酶衰减蛋白1抗体英文名称  Anti-phospho-DOK1(Tyr362) 
中文名称  磷酸化D酪氨酸激酶衰减蛋白1抗体 
别    名  DOK1 (phospho Y362); DOK1 (phospho Tyr362); p-DOK1 (phospho Y362); docking protein 1 (downstream of tyrosine kinase 1); Docking protein 1 (p62(dok)) (Downstream of tyrosine kinase 1) (pp62).; docking protein 1 62kD (downstream of tyrosine kinase 1); Docking protein 1 62kD; Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK-1; DOK1_HUMAN; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62; pp62. 
公司磷酸化D酪氨酸激酶衰减蛋白1抗体应用于医学免疫学、动物免疫学、分子生物学、生物化学、临床医学、检验医学、动物医学、药学、理工、农学、环境学等生命科学密切相关的专业。           
浓    度  1mg/1ml 
规 格  0.1ml/100μg          
抗体来源  Rabbit  
克隆类型  polyclonal 
交叉反应  Human, Mouse, Rat, Dog, Pig, Cow   
产品类型  一抗  磷酸化抗体   
研究领域  肿瘤 心血管 信号转导 细胞凋亡 G蛋白偶联受体  
蛋白分子量  predicted molecular weight: 62kDa 
性    状  Lyophilized or Liquid 
免 疫 原  KLH conjugated Synthesised phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr362 
亚    型  IgG 
纯化方法  affinity purified by Protein A 
储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 
产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  IF=1:100-500 
(石蜡切片需做抗原修复) 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
磷酸化D酪氨酸激酶衰减蛋白1抗体产品介绍 Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Function : DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Subunit : Interacts with ABL1 (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3.
Subcellular Location : Isoform 1: Cytoplasm. Isoform 3: Cytoplasm, perinuclear region.
Tissue Specificity : Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.
Post-translational modifications : Constitutively tyrosine-phosphorylated. Phosphorylated by TEC. Phosphorylated by LYN.
Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway.
Isoform 3 contains a N-acetylmethionine at position 1.
Similarity : Belongs to the DOK family. Type A subfamily.
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.
Database links : UniProtKB/Swiss-Prot: Q99704.1
【存储要求】连续使用时4°C存储,保质期六个月;磷酸化D酪氨酸激酶衰减蛋白1抗体期存储时建议分装为10ul以上小包装-20°C存储,并避免反复冻融,保质期一年。
实验的用途:
1)WB:Western Blotting 免疫印迹
2)IH:Immunohistochemistry 免疫组化
3)IH(P):Immunohistochemistry Parraffin sections 免疫组化(石蜡)
4)IH(F):Immunohistochemistry Frozen sections 免疫组化(冰冻)
5)IC:Immunocytochemistry 免疫细胞化学
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上海基免实业有限公司

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2013-03-11

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